Genetic basis of endometriosis

被引：52

作者：

Bischoff, F

Simpson, JL

机构：

[1] Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

来源：

UTERUS AND HUMAN REPRODUCTION | 2004年 / 1034卷

关键词：

endometriosis; heritability; candidate genes;

D O I：

10.1196/annals.1335.030

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Endometriosis is a complex gynecologic disorder that has long been recognized as showing heritable tendencies, with recurrence risks of 5-7% for first-degree relatives. Familial and epidemiologic studies support that this disease is a genetic disorder of polygenic/multifactorial inheritance. The current investigational challenge is to determine the number and location of causative genes. Recent advances in molecular technology make identification and elucidation of these genes now possible. In this review, we update previous communications in which we also reviewed heritability studies supporting polygenic/multifactorial inheritance, discuss the scientific basis of genomewide strategies for identifying causative genes, and identify potential candidate genes.

引用

页码：284 / 299

页数：16

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