Sialyl Lewis X polysaccharide conjugates: Targeting inflammatory lesions

被引：11

作者：

Sakagami, M ^{[1
]}

Horie, K ^{[1
]}

Nakamoto, K ^{[1
]}

Kawaguchi, T ^{[1
]}

Hamana, H ^{[1
]}

机构：

[1] Drug Delivery Syst Inst Ltd, Noda, Chiba 278, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(98)00488-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel system for active targeting of inflammatory lesions has been established. A SLe(X)-CMPul conjugate (2) showed accumulation that was 2.5-fold higher in inflammatory lesions in vivo than a SLN-CMPul conjugate (4) and 300-fold higher than monovalent SLe(X) (6). (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2783 / 2786

页数：4

共 28 条

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