Stopping time: The genetics of fly and mouse circadian clocks

被引:253
作者
Allada, R [1 ]
Emery, P
Takahashi, JS
Rosbash, M
机构
[1] Howard Hughes Med Inst, Evanston, IL 60208 USA
[2] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA
[3] Brandeis Univ, Dept Biol, Waltham, MA 02454 USA
关键词
circadian; bHLH-PAS; period; cryptochrome; casein kinase I epsilon;
D O I
10.1146/annurev.neuro.24.1.1091
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Forward genetic analyses in flies and mice have uncovered conserved transcriptional feedback loops at the heart of circadian pacemakers. Conserved mechanisms of posttranslational regulation, most notably phosphorylation, appear to be important for timing feedback. Transcript analyses have indicated that circadian clocks are not restricted to neurons but are found in several tissues. Comparisons between flies and mice highlight important differences in molecular circuitry and circadian organization. Future studies of pacemaker mechanisms and their control of physiology and behavior will likely continue to rely on forward genetics.
引用
收藏
页码:1091 / 1119
页数:29
相关论文
共 161 条
[52]  
Hastings M H, 1999, J Neurosci, V19, pRC11
[53]   Rhythmic expression of a PER-reporter in the malpighian tubules of decapitated Drosophila: Evidence for a brain-independent circadian clock [J].
Hege, DM ;
Stanewsky, R ;
Hall, JC ;
Giebultowicz, JM .
JOURNAL OF BIOLOGICAL RHYTHMS, 1997, 12 (04) :300-308
[55]   Rest in Drosophila is a sleep-like state [J].
Hendricks, JC ;
Finn, SM ;
Panckeri, KA ;
Chavkin, J ;
Williams, JA ;
Sehgal, A ;
Pack, AI .
NEURON, 2000, 25 (01) :129-138
[56]  
Hogenesch JB, 2000, J NEUROSCI, V20, part. no.
[57]   The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors [J].
Hogenesch, JB ;
Gu, YZ ;
Jain, SJ ;
Bradfield, CA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (10) :5474-5479
[58]   PAS IS A DIMERIZATION DOMAIN COMMON TO DROSOPHILA PERIOD AND SEVERAL TRANSCRIPTION FACTORS [J].
HUANG, ZJ ;
EDERY, I ;
ROSBASH, M .
NATURE, 1993, 364 (6434) :259-262
[59]   Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light [J].
HunterEnsor, M ;
Ousley, A ;
Sehgal, A .
CELL, 1996, 84 (05) :677-685
[60]   Biological clocks [J].
Ishida, N ;
Kaneko, M ;
Allada, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (16) :8819-8820