Implementation of multichannel sensors for remote biomedical measurements in a microsystems format

被引:91
作者
Johannessen, EA
Wang, L
Cui, L
Tang, TB
Ahmadian, M
Astaras, A
Reid, SWJ
Murray, AF
Flynn, BW
Beaumont, SP
Cumming, DRS
Cooper, JM
机构
[1] Univ Glasgow, Dept Elect & Elect Engn, Glasgow G12 8LT, Lanark, Scotland
[2] Univ Edinburgh, Sch Engn & Elect, Edinburgh EH9 3JL, Midlothian, Scotland
[3] Alba Ctr, Inst Syst Level Integrat, Livingston EH54 7EG, Scotland
[4] Univ Glasgow, Sch Vet, Inst Comparat Med, Dept Vet Clin Studies, Glasgow G61 1QH, Lanark, Scotland
[5] Univ Strathclyde, Dept Stat & Modeling Sci, Glasgow G1 1XW, Lanark, Scotland
关键词
microelectronic pill; microsensor integration; mobile analytical microsystem; multilayer silicon fabrication; radiotelemetry; remote in situ measurements;
D O I
10.1109/TBME.2003.820370
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A novel microelectronic "pill" has been developed for in situ studies of the gastro-intestinal tract, combining microsensors and integrated circuits with system-level integration technology. The measurement parameters include real-time remote recording of temperature, pH, conductivity, and dissolved oxygen. The unit comprises an outer biocompatible capsule encasing four microsensors, a control chip, a discrete component radio transmitter, and two silver oxide cells (the latter providing an operating time of 40 h at the rated power consumption of 12.1 mW). The sensors were fabricated on two separate silicon chips located at the front end of the capsule. The robust nature of the pill makes it adaptable for use in a variety of environments related to biomedical and industrial applications..
引用
收藏
页码:525 / 535
页数:11
相关论文
共 35 条
[1]  
ASADA G, 1997, P 1997 IEEE INT S CI, V4, P2817
[2]   Gel-integrated microelectrode arrays for direct voltammetric measurements of heavy metals in natural waters and other complex media [J].
Belmont-Hébert, C ;
Tercier, ML ;
Buffle, J ;
Fiaccabrino, GC ;
de Rooij, NF ;
Koudelka-Hep, M .
ANALYTICAL CHEMISTRY, 1998, 70 (14) :2949-2956
[4]   Exposure to low oxygen tension and increased osmolarity enhance the ability of Mycobacterium avium to enter intestinal epithelial (HT-29) cells [J].
Bermudez, LE ;
Petrofsky, M ;
Goodman, J .
INFECTION AND IMMUNITY, 1997, 65 (09) :3768-3773
[5]   TIME-DEPENDENCE OF THE CHEMICAL RESPONSE OF SILICON-NITRIDE SURFACES [J].
BOUSSE, L ;
HAFEMAN, D ;
TRAN, N .
SENSORS AND ACTUATORS B-CHEMICAL, 1990, 1 (1-6) :361-367
[6]   Microtechnologies for pH ISFET chemical sensors [J].
Cane, C ;
Gracia, I ;
Merlos, A .
MICROELECTRONICS JOURNAL, 1997, 28 (04) :389-405
[7]   Electromagnetic radiation from ingested sources in the human intestine between 150 MHz and 1.2 GHz [J].
Chirwa, LC ;
Hammond, PA ;
Roy, S ;
Cumming, DRS .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2003, 50 (04) :484-492
[8]   ELECTRODE SYSTEMS FOR CONTINUOUS MONITORING IN CARDIOVASCULAR SURGERY [J].
CLARK, LC ;
LYONS, C .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1962, 102 (01) :29-&
[9]  
COLSON RH, 1981, BIOTELEM PAT MON, V8, P213
[10]  
Dawson R.M. C., 1986, DATA BIOCH RES