A Novel Type of Complex Ganglion Cell in Rabbit Retina

被引:18
作者
Sivyer, Benjamin [1 ]
Venkataramani, Sowmya [2 ]
Taylor, W. Rowland [2 ]
Vaney, David I. [1 ]
机构
[1] Univ Queensland, Queensland Brain Inst, ARC Ctr Excellence Vis Sci, Brisbane, Qld 4072, Australia
[2] Oregon Hlth & Sci Univ, Casey Eye Inst, Dept Ophthalmol, Portland, OR 97239 USA
基金
澳大利亚研究理事会; 英国医学研究理事会; 美国国家卫生研究院;
关键词
retinal ganglion cell; ON-OFF cell; spike recording; voltage-clamp recording; MOUSE RETINA; BIPOLAR CELLS; CAT RETINA; RECEPTIVE-FIELDS; MAMMALIAN RETINA; AMACRINE CELLS; ON-CENTER; DIRECTION; MORPHOLOGY; RESPONSES;
D O I
10.1002/cne.22720
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The 15-20 physiological types of retinal ganglion cells (RGCs) can be grouped according to whether they fire to increased illumination in the receptive-field center (ON cells), decreased illumination (OFF cells), or both (ON-OFF cells). The diversity of RGCs has been best described in the rabbit retina, which has three types of ON-OFF RGCs with complex receptive-field properties: the ON-OFF direction-selective ganglion cells (DSGCs), the local edge detectors, and the uniformity detectors. Here we describe a novel type of bistratified ON-OFF RGC that has not been described in either physiological or morphological studies of rabbit RGCs. These cells stratify in the ON and OFF sublaminae of the inner plexiform layer, branching at about 30% and 60% depth, between the ON and OFF arbors of the bistratified DSGCs. Similar to the ON-OFF DSGCs, these cells respond with transient firing to both bright and dark spots flashed in the receptive field but, unlike the DSGCs, they show no directional preference for moving stimuli. We have termed these cells "transient ON-OFF'' RGCs. Area-response measurements show that both the ON and the OFF spike responses have an antagonistic receptive-field organization, but with different spatial extents. Voltage-clamp recordings reveal transient excitatory inputs at light ON and light OFF; this excitation is strongly suppressed by surround stimulation, which also elicits direct inhibitory inputs to the cells at light ON and light OFF. Thus the receptive-field organization is mediated both within the presynaptic circuitry and by direct feed-forward inhibition. J. Comp. Neurol. 519:3128-3138, 2011. (C) 2011 Wiley-Liss, Inc.
引用
收藏
页码:3128 / 3138
页数:11
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