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Transgenic and knockout mice in the study of neurodegenerative diseases

被引：33
作者：
Aguzzi, A
Brandner, S
Marino, S
Steinbach, JP
机构：
[1] Institute of Neuropathology, Department of Pathology, CH-8091 Zürich
来源：
JOURNAL OF MOLECULAR MEDICINE-JMM | 1996年 / 74卷 / 03期
关键词：
neurodegeneration; transgenic mouse; prions; spumavirinae; Alzheimer's disease; amyotrophic lateral sclerosis;
D O I：
10.1007/BF01575443
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Accurate animal models are essential for detailed analysis of the mechanisms underlying human neurodegenerative diseases. In addition, they can offer useful paradigms for the development and evaluation of new therapeutic strategies. We review the most popular techniques for modification of the mammalian genome in vivo, and provide a critical evaluation of the available transgenic mouse models for several neurological condition of humans, including prion diseases, human retroviral diseases, Alzheimer's disease, and motor neuron diseases.
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页码：111 / 126
页数：16
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