Synthesis of bridged analogs of epibatidine. 3-chloro-5,7,8,9,9a,10-hexahydro-7,10-methanopyrrolo[1,2-b]-2,6-naphthyridine and 2-chloro-5,5a,6,7,8,10-hexahydro-5,8-methanopyrrolo[2,1-b]-1,7-naphthyridine

被引：23

作者：

Brieaddy, LE

Mascarella, SW

Navarro, HA

Atkinson, RN

Damaj, MI

Martin, BR

Carroll, FI

机构：

[1] Res Triangle Inst, Res Triangle Pk, NC 27709 USA

[2] Virginia Commonwealth Univ, Coll Med, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(01)00575-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of conformationally locked analogs of epibatidine are described in which the key step is an intramolecular reductive palladium-catalyzed Heck-type coupling. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3795 / 3797

页数：3

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