Prevention of chronic allograft rejection by Vitamin D receptor agonists

被引：27

作者：

Adorini, L ^{[1
]}

Amuchastegui, S ^{[1
]}

Daniel, KC ^{[1
]}

机构：

[1] BioXell, I-20132 Milan, Italy

来源：

IMMUNOLOGY LETTERS | 2005年 / 100卷 / 01期

关键词：

vitamin D receptor agonists; chronic allograft rejection; immunomodulation;

D O I：

10.1016/j.imlet.2005.06.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

While immunosuppressive drugs now permit a good control of acute allograft rejection, chronic rejection remains an important unmet medical problem. We propose that Vitamin D receptor (VDR) agonists, secosteroid hormones that control cell proliferation and differentiation and exert immunoregulatory activities, in addition to regulate calcium and bone metabolism, have the potential to contribute to the management of chronic allograft rejection. Recent advances in understanding the immunomodulatory and growth-regulating properties of VDR agonists indicate the clinical applicability of these hormones in transplantation, with the aim of facilitating tolerance induction and preventing chronic graft rejection. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：34 / 41

页数：8

共 83 条

[1] Pharmacological induction of tolerogenic dendritic cells and regulatory T cells [J].