New Insights into the Regulation of Signalling by Toll-Like Receptors and Nod-Like Receptors

被引：114

作者：

Coll, Rebecca C. ^{[1
]}

O'Neill, Luke A. J. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Sch Biochem & Immunol, Lab 1 1, Inflammat Res Grp, Dublin 2, Ireland

来源：

JOURNAL OF INNATE IMMUNITY | 2010年 / 2卷 / 05期

基金：

爱尔兰科学基金会;

关键词：

miRNA; Negative regulation; Nod-like receptor; Toll-like receptor; Ubiquitination; NF-KAPPA-B; FAMILIAL MEDITERRANEAN FEVER; INFLAMMATORY RESPONSE; CASPASE-1; ACTIVATION; NEGATIVE REGULATION; NLRP3; INFLAMMASOME; INNATE IMMUNITY; SPLICE VARIANT; UP-REGULATION; ENZYME A20;

D O I：

10.1159/000315469

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The activation of Toll-Like receptors (TLRs) and Nod-like receptors (NLRs) triggers intracellular signalling pathways that lead to effector mechanisms in innate immunity and inflammation. The negative regulation of TLR signalling has been extensively studied. Current areas of research include post-transcriptional regulation by miRNA, post-translational regulation by ubiquitination and regulation by splice variants such as MyD88s, TRAM adaptor with GOLD domain and IRAK2 isoforms. The negative regulation of NLR signalling is a relatively new area of research. Examples include a splice variant of NOD2, the ubiquitin editing enzyme A20, pyrin domain-only proteins and caspase recruitment domain-only proteins which all have a negative effect on NOD2 or NLRP3 signalling. A greater understanding of the mechanisms underlying the negative control of TLR and NLR signalling may provide new targets for therapeutic intervention. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：406 / 421

页数：16

共 90 条

[1] Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients [J].

Adib-Conquy, Minou ;

Adrie, Christophe ;

Fitting, Catherine ;

Gattolliat, Olivier ;

Beyaert, Rudi ;

Cavaillon, Jean-Marc .

CRITICAL CARE MEDICINE, 2006, 34 (09) :2377-2385

[2] NALP3 forms an IL-lβ-Processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder [J].

Agostini, L ;

Martinon, F ;

Burns, K ;

McDermott, MF ;

Hawkins, PN ;

Tschopp, J .

IMMUNITY, 2004, 20 (03) :319-325

[3] The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs [J].

Androulidaki, Ariadne ;

Iliopoulos, Dimitrios ;

Arranz, Alicia ;

Doxaki, Christina ;

Schworer, Steffen ;

Zacharioudaki, Vassiliki ;

Margioris, Andrew N. ;

Tsichlis, Philip N. ;

Tsatsanis, Christos .

IMMUNITY, 2009, 31 (02) :220-231

[4] MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer [J].

Asangani, I. A. ;

Rasheed, S. A. K. ;

Nikolova, D. A. ;

Leupold, J. H. ;

Colburn, N. H. ;

Post, S. ;

Allgayer, H. .

ONCOGENE, 2008, 27 (15) :2128-2136

[5] MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[6] Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression [J].

Bauernfeind, Franz G. ;

Horvath, Gabor ;

Stutz, Andrea ;

Alnemri, Emad S. ;

MacDonald, Kelly ;

Speert, David ;

Fernandes-Alnemri, Teresa ;

Wu, Jianghong ;

Monks, Brian G. ;

Fitzgerald, Katherine A. ;

Hornung, Veit ;

Latz, Eicke .

JOURNAL OF IMMUNOLOGY, 2009, 183 (02) :787-791

[7] Pyrin-only protein 2 modulates NFκB and disrupts ASC:CLR interactions [J].

Bedoya, Felipe ;

Sandler, Laurel L. ;

Harton, Jonathan A. .

JOURNAL OF IMMUNOLOGY, 2007, 178 (06) :3837-3845

[8] Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2 [J].

Bertrand, Mathieu J. M. ;

Doiron, Karine ;

Labbe, Katherine ;

Korneluk, Robert G. ;

Barker, Philip A. ;

Saleh, Maya .

IMMUNITY, 2009, 30 (06) :789-801

[9] The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses [J].

Boone, DL ;

Turer, EE ;

Lee, EG ;

Ahmad, RC ;

Wheeler, MT ;

Tsui, C ;

Hurley, P ;

Chien, M ;

Chai, S ;

Hitotsumatsu, O ;

McNally, E ;

Pickart, C ;

Ma, A .

NATURE IMMUNOLOGY, 2004, 5 (10) :1052-1060

[10] Bcl-2 and Bcl-XL regulate proinf lammatory caspase-1 activation by interaction with NALP1 [J].

Bruey, Jean-Marie ;

Bruey-Sedano, Nathalie ;

Luciano, Frederic ;

Zhai, Dayong ;

Balpai, Ruchi ;

Xu, Chunyan ;

Kress, Christina L. ;

Bailly-Maitre, Beatrice ;

Li, Xiaoqing ;

Osterman, Andrei ;

Matsuzawa, Shu-ichi ;

Terskikh, Alexey V. ;

Faustin, Benjamin ;

Reed, John C. .

CELL, 2007, 129 (01) :45-56

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