New Insights into the Regulation of Signalling by Toll-Like Receptors and Nod-Like Receptors

被引：116

作者：

Coll, Rebecca C. ^{[1
]}

O'Neill, Luke A. J. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Sch Biochem & Immunol, Lab 1 1, Inflammat Res Grp, Dublin 2, Ireland

来源：

JOURNAL OF INNATE IMMUNITY | 2010年 / 2卷 / 05期

基金：

爱尔兰科学基金会;

关键词：

miRNA; Negative regulation; Nod-like receptor; Toll-like receptor; Ubiquitination; NF-KAPPA-B; FAMILIAL MEDITERRANEAN FEVER; INFLAMMATORY RESPONSE; CASPASE-1; ACTIVATION; NEGATIVE REGULATION; NLRP3; INFLAMMASOME; INNATE IMMUNITY; SPLICE VARIANT; UP-REGULATION; ENZYME A20;

D O I：

10.1159/000315469

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The activation of Toll-Like receptors (TLRs) and Nod-like receptors (NLRs) triggers intracellular signalling pathways that lead to effector mechanisms in innate immunity and inflammation. The negative regulation of TLR signalling has been extensively studied. Current areas of research include post-transcriptional regulation by miRNA, post-translational regulation by ubiquitination and regulation by splice variants such as MyD88s, TRAM adaptor with GOLD domain and IRAK2 isoforms. The negative regulation of NLR signalling is a relatively new area of research. Examples include a splice variant of NOD2, the ubiquitin editing enzyme A20, pyrin domain-only proteins and caspase recruitment domain-only proteins which all have a negative effect on NOD2 or NLRP3 signalling. A greater understanding of the mechanisms underlying the negative control of TLR and NLR signalling may provide new targets for therapeutic intervention. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：406 / 421

页数：16

共 90 条

[31] The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals [J].

Hitotsumatsu, Osamu ;

Ahmad, Regina-Celeste ;

Tavares, Rita ;

Wang, Min ;

Philpott, Dana ;

Turer, Emre E. ;

Lee, Bettina L. ;

Shiffin, Nataliya ;

Advincula, Rommel ;

Malynn, Barbara A. ;

Werts, Catherine ;

Ma, Averil .

IMMUNITY, 2008, 28 (03) :381-390

[32] MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2 [J].

Hou, Jin ;

Wang, Pin ;

Lin, Li ;

Liu, Xingguang ;

Ma, Feng ;

An, Huazhang ;

Wang, Zhugang ;

Ca, Xuetao .

JOURNAL OF IMMUNOLOGY, 2009, 183 (03) :2150-2158

[33] A NOD2-NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide [J].

Hsu, Li-Chung ;

Ali, Syed R. ;

McGillivray, Shauna ;

Tseng, Ping-Hui ;

Mariathasan, Sanjeev ;

Humke, Eric W. ;

Eckmann, Lars ;

Powell, Jonathan J. ;

Nizet, Victor ;

Dixit, Vishva M. ;

Karin, Michael .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (22) :7803-7808

[34] The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens [J].

Hsu, Yen-Michael S. ;

Zhang, Yongliang ;

You, Yun ;

Wang, Donghai ;

Li, Hongxiu ;

Duramad, Omar ;

Qin, Xiao-Feng ;

Dong, Chen ;

Lin, Xin .

NATURE IMMUNOLOGY, 2007, 8 (02) :198-205

[35] ICEBERG:: A novel inhibitor of interleukin-1β generation [J].

Humke, EW ;

Shriver, SK ;

Starovasnik, MA ;

Fairbrother, WJ ;

Dixit, VM .

CELL, 2000, 103 (01) :99-111

[36] Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome [J].

Iyer, Shankar S. ;

Pulskens, Wilco P. ;

Sadler, Jeffrey J. ;

Butter, Loes M. ;

Teske, Gwendoline J. ;

Ulland, Tyler K. ;

Eisenbarth, Stephanie C. ;

Florquin, Sandrine ;

Flavell, Richard A. ;

Leemans, Jaklien C. ;

Sutterwala, Fayyaz S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (48) :20388-20393

[37] MyD88S, a splice variant of MyD88, differentially modulates NF-κB- and AP-1-dependent gene expression [J].

Janssens, S ;

Burns, K ;

Vercammen, E ;

Tschopp, J ;

Beyaert, R .

FEBS LETTERS, 2003, 548 (1-3) :103-107

[38] Regulation of interleukin-1-and lipopolysaccharide-induced NF-κB activation by alternative splicing of MyD88 [J].

Janssens, S ;

Burns, K ;

Tschopp, J ;

Beyaert, R .

CURRENT BIOLOGY, 2002, 12 (06) :467-471

[39] TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis [J].

Kawagoe, Tatsukata ;

Takeuchi, Osamu ;

Takabatake, Yoshitsugu ;

Kato, Hiroki ;

Isaka, Yoshitaka ;

Tsujimura, Tohru ;

Akira, Shizuo .

NATURE IMMUNOLOGY, 2009, 10 (09) :965-U53

[40] Active caspase-1 is a regulator of unconventional protein secretion [J].

Keller, Martin ;

Rueegg, Andreas ;

Werner, Sabine ;

Beer, Hans-Dietmar .

CELL, 2008, 132 (05) :818-831

← 1 2 3 4 5 6 7 8 9 →