共 33 条
The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens
被引:356
作者:

Hsu, Yen-Michael S.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

Zhang, Yongliang
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

You, Yun
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

Wang, Donghai
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

Li, Hongxiu
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

Duramad, Omar
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

Qin, Xiao-Feng
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

Dong, Chen
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

Lin, Xin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA
机构:
[1] Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA
[2] Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA
[3] Harvard Univ, Sch Med, CBR Inst Biomed Res, Boston, MA 02115 USA
基金:
美国国家卫生研究院;
关键词:
D O I:
10.1038/ni1426
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
The caspase-recruitment domain-containing adaptor protein CARD9 regulates the innate signaling responses to fungal infection. Here we show that CARD9 is required for innate immune responses against intracellular pathogens. We generated Card9(-/-) mice and found that CARD9-deficient macrophages had defects in activation of the kinases p38 and Jnk but not of transcription factor NF-kappa B after bacterial and viral infection. CARD9-deficient mice failed to clear infection and showed altered cytokine production after challenge with Listeria monocytogenes. In wild-type cells, we found CARD9 inducibly associated with both the intracellular 'biosensor' Nod2 and the serine-threonine kinase RICK. Our data demonstrate that CARD9 has a critical function in Nod2-mediated activation of p38 and Jnk in innate immune responses to intracellular pathogens.
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页码:198 / 205
页数:8
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