Novel N-ferrocenylmethyl, N′-methyl-2-substituted benzimidazolium iodide salts with in vitro activity against the P-falciparum malarial parasite strain NF54

被引：41

作者：

Howarth, J ^{[1
]}

Hanlon, K ^{[1
]}

机构：

[1] Dublin City Univ, Sch Chem Sci, Dublin 9, Ireland

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 04期

关键词：

Plasmodium falciparum; antimalaria; benzimidazolium salts;

D O I：

10.1016/S0040-4039(00)02106-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein we disclose results of our research into a novel class of benzimidazolium compounds active against malarial parasites. We have discovered that N-ferrocenylmethyl, N'-methyl-2-aryl (or styryl) benzimidazolium iodide salts show excellent in vitro activity against the P. falciparum malarial parasite strain NF54. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：751 / 754

页数：4

相关论文

共 20 条

[1] HEXOSE-MONOPHOSPHATE SHUNT ACTIVITY IN INTACT PLASMODIUM-FALCIPARUM-INFECTED ERYTHROCYTES AND IN FREE PARASITES [J].

ATAMNA, H ;

PASCARMONA, G ;

GINSBURG, H .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1994, 67 (01) :79-89

[2] Mode of antimalarial effect of methylene blue and some of its analogues on Plasmodium falciparum in culture and their inhibition of P-vinckei petteri and P-yoelii nigeriensis in vivo [J].

Atamna, H ;

Krugliak, M ;

Shalmiev, G ;

Deharo, E ;

Pescarmona, G ;

Ginsburg, H .

BIOCHEMICAL PHARMACOLOGY, 1996, 51 (05) :693-700

[3] CYTOCHEMICAL AND BIOCHEMICAL STUDIES OF YEASTS AFTER INVITRO EXPOSURE TO MICONAZOLE [J].

DENOLLIN, S ;

VANBELLE, H ;

GOOSSENS, F ;

THONE, F ;

BORGERS, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1977, 11 (03) :500-513

[4]

Ehrlich P., 1956, Collected Papers of Paul Ehrlich

[5]

FAEBER PM, 1998, FEBS LETT, V422, P311

[6]

FULLERTON DS, 1990, MED LETT, V31, P13

[7] THE USE OF POLYPHOSPHORIC ACID IN THE SYNTHESIS OF 2-ARYL-SUBSTITUTED AND 2-ALKYL-SUBSTITUTED BENZIMIDAZOLES, BENZOXAZOLES AND BENZOTHIAZOLES [J].

HEIN, DW ;

ALHEIM, RJ ;

LEAVITT, JJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1957, 79 (02) :427-429

[8] Moisture stable ambient temperature ionic liquids: Solvents for the new millennium. 1. The heck reaction [J].

Howarth, J ;

Dallas, A .

MOLECULES, 2000, 5 (06) :851-855

[9] 1,3-di(ferrocenylmethyl)imidazolium and 1-ferrocenylmethyl-3-alkylimidazolium salts: A high yield and facile synthesis [J].

Howarth, J ;

Thomas, JL ;

Hanlon, K ;

McGuirk, D .

SYNTHETIC COMMUNICATIONS, 2000, 30 (10) :1865-1878

[10] Oxidation of aromatic aldehydes in the ionic liquid [bmim]PF6 [J].

Howarth, J .

TETRAHEDRON LETTERS, 2000, 41 (34) :6627-6629