Novel N-ferrocenylmethyl, N′-methyl-2-substituted benzimidazolium iodide salts with in vitro activity against the P-falciparum malarial parasite strain NF54

被引：41

作者：

Howarth, J ^{[1
]}

Hanlon, K ^{[1
]}

机构：

[1] Dublin City Univ, Sch Chem Sci, Dublin 9, Ireland

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 04期

关键词：

Plasmodium falciparum; antimalaria; benzimidazolium salts;

D O I：

10.1016/S0040-4039(00)02106-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein we disclose results of our research into a novel class of benzimidazolium compounds active against malarial parasites. We have discovered that N-ferrocenylmethyl, N'-methyl-2-aryl (or styryl) benzimidazolium iodide salts show excellent in vitro activity against the P. falciparum malarial parasite strain NF54. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：751 / 754

页数：4

共 20 条

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