Efficient asymmetric epoxidation of α,β-unsaturated ketones using a soluble triblock polyethylene glycol-polyamino acid catalyst

被引：75

作者：

Flood, RW ^{[1
]}

Geller, TP ^{[1
]}

Petty, SA ^{[1
]}

Roberts, SM ^{[1
]}

Skidmore, J ^{[1
]}

Volk, M ^{[1
]}

机构：

[1] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 05期

关键词：

D O I：

10.1021/ol007005l

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Polyethylene glycol (PEG)-bound poly-L leucine acts as a THF-soluble catalyst for the Julia-Colonna asymmetric epoxidation of enones, Excellent enantioselectivities may be obtained even with short chain length polyleucine. FT-IR investigations have determined that the catalytically active polyleucine components of these copolymers have an alpha -helical structure.

引用

页码：683 / 686

页数：4

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