Optimal control strategies for simultaneous saccharification and fermentation of starch

被引:23
作者
Roy, S [1 ]
Gudi, RD [1 ]
Venkatesh, KV [1 ]
Shah, SS [1 ]
机构
[1] Indian Inst Technol, Dept Chem Engn, Mumbai 400076, India
关键词
optimal control; simultaneous saccharification and fermentation; fed-batch fermentation; multiple feed optimization; end point constraint;
D O I
10.1016/S0032-9592(00)00270-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Design and analysis of optimal control strategies for three types of inhibitory fed-batch bioprocesses have been discussed. These are simple saccharification (SS) of starch to glucose, simple fermentation (SF) of derived glucose to lactic acid (LA) and simultaneous saccharification and fermentation (SSF) of starch to LA. Various optimal feeding strategies have been investigated for the SSF process by manipulating starch addition rates. To avoid the complexity of solving a singular problem, the starch addition rates are expressed in terms of the broth volume, which is used as a control variable. The optimization strategy is thus solved in a nonsingular framework. Experimental studies carried out using the results of the optimization demonstrated the accuracy and utility of the approach. An increase of 20% in lactate productivity was obtained by operating the SSF process in a fed-batch mode. The focus of all the optimization studies has been to improve the performance of the SSF process. Optimal control of starch additions in the fed-batch process gave improved performance of the SSF process. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:713 / 722
页数:10
相关论文
共 19 条
[1]  
[Anonymous], OPTIMIZATION TECHNIQ
[2]  
[Anonymous], 2018, Mathematical Theory of Optimal Processes
[3]   Simultaneous saccharification and fermentation of starch to lactic acid [J].
Anuradha, R ;
Suresh, AK ;
Venkatesh, KV .
PROCESS BIOCHEMISTRY, 1999, 35 (3-4) :367-375
[4]  
ANURADHA R, 1999, THESIS INDIAN I TECH
[5]  
Bryson A. E., 1975, APPL OPTIMAL CONTROL
[6]   ON THE OPTIMAL-CONTROL OF FED-BATCH REACTORS WITH SUBSTRATE-INHIBITED KINETICS [J].
CAZZADOR, L .
BIOTECHNOLOGY AND BIOENGINEERING, 1988, 31 (07) :670-674
[7]   OPTIMAL SUBSTRATE PROFILE FOR ANTIBIOTIC FERMENTATIONS [J].
GUTHKE, R ;
KNORRE, WA .
BIOTECHNOLOGY AND BIOENGINEERING, 1981, 23 (12) :2771-2777
[8]   OPTIMAL SUBSTRATE FEEDING POLICY FOR A FED BATCH FERMENTATION WITH SUBSTRATE AND PRODUCT INHIBITION-KINETICS [J].
HONG, J .
BIOTECHNOLOGY AND BIOENGINEERING, 1986, 28 (09) :1421-1431
[9]   OPTIMAL NONSINGULAR CONTROL OF FED-BATCH FERMENTATION [J].
KURTANJEK, Z .
BIOTECHNOLOGY AND BIOENGINEERING, 1991, 37 (09) :814-823
[10]   GENERAL-CHARACTERISTICS OF OPTIMAL FEED RATE PROFILES FOR VARIOUS FED-BATCH FERMENTATION PROCESSES [J].
MODAK, JM ;
LIM, HC ;
TAYEB, YJ .
BIOTECHNOLOGY AND BIOENGINEERING, 1986, 28 (09) :1396-1407