Microsatellite instability generates diversity in brain and sociobehavioral traits

被引：372

作者：

Hammock, EAD ^{[1
]}

Young, LJ ^{[1
]}

机构：

[1] Emory Univ, Yerkes Natl Primate Res Ctr, Ctr Behav Neurosci, Dept Psychiat & Behav Sci, Atlanta, GA 30329 USA

来源：

SCIENCE | 2005年 / 308卷 / 5728期

关键词：

D O I：

10.1126/science.1111427

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Repetitive microsatellites mutate at relatively high rates and may contribute to the rapid evolution of species-typical traits. We show that individual alleles of a repetitive polymorphic microsatellite in the 5' region of the prairie vole vasopressin 1a receptor (avpr1a) gene modify gene expression in vitro. In vivo, we observe that this regulatory polymorphism predicts both individual differences in receptor distribution patterns and socio-behavioral traits. These data suggest that individual differences in gene expression patterns may be conferred via polymorphic microsatellites in the cis-regulatory regions of genes and may contribute to normal variation in behavioral traits.

引用

页码：1630 / 1634

页数：5

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