Microsatellite instability generates diversity in brain and sociobehavioral traits

被引:372
作者
Hammock, EAD [1 ]
Young, LJ [1 ]
机构
[1] Emory Univ, Yerkes Natl Primate Res Ctr, Ctr Behav Neurosci, Dept Psychiat & Behav Sci, Atlanta, GA 30329 USA
关键词
D O I
10.1126/science.1111427
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Repetitive microsatellites mutate at relatively high rates and may contribute to the rapid evolution of species-typical traits. We show that individual alleles of a repetitive polymorphic microsatellite in the 5' region of the prairie vole vasopressin 1a receptor (avpr1a) gene modify gene expression in vitro. In vivo, we observe that this regulatory polymorphism predicts both individual differences in receptor distribution patterns and socio-behavioral traits. These data suggest that individual differences in gene expression patterns may be conferred via polymorphic microsatellites in the cis-regulatory regions of genes and may contribute to normal variation in behavioral traits.
引用
收藏
页码:1630 / 1634
页数:5
相关论文
共 38 条
[31]   PARENTAL CARE AND MATING SYSTEM OF THE PRAIRIE VOLE, MICROTUS-OCHROGASTER [J].
THOMAS, JA ;
BIRNEY, EC .
BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY, 1979, 5 (02) :171-186
[32]   ROLE OF SEPTAL VASOPRESSIN INNERVATION IN PATERNAL BEHAVIOR IN PRAIRIE VOLES (MICROTUS-OCHROGASTER) [J].
WANG, ZX ;
FERRIS, CF ;
DEVRIES, GJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (01) :400-404
[33]   Examination of AVPR1a as an autism susceptibility gene [J].
Wassink, TH ;
Piven, J ;
Vieland, VJ ;
Pietila, J ;
Goedken, RJ ;
Folstein, SE ;
Sheffield, VC .
MOLECULAR PSYCHIATRY, 2004, 9 (10) :968-972
[34]   OLFACTORY-BULB REMOVAL AFFECTS PARTNER PREFERENCE DEVELOPMENT AND ESTRUS INDUCTION IN FEMALE PRAIRIE VOLES [J].
WILLIAMS, JR ;
SLOTNICK, BM ;
KIRKPATRICK, BW ;
CARTER, CS .
PHYSIOLOGY & BEHAVIOR, 1992, 52 (04) :635-639
[35]   The evolution of transcriptional regulation in eukaryotes [J].
Wray, GA ;
Hahn, MW ;
Abouheif, E ;
Balhoff, JP ;
Pizer, M ;
Rockman, MV ;
Romano, LA .
MOLECULAR BIOLOGY AND EVOLUTION, 2003, 20 (09) :1377-1419
[36]   Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole [J].
Young, LJ ;
Nilsen, R ;
Waymire, KG ;
MacGregor, GR ;
Insel, TR .
NATURE, 1999, 400 (6746) :766-768
[37]   Species differences in V(1)a receptor gene expression in monogamous and nonmonogamous voles: Behavioral consequences [J].
Young, LJ ;
Winslow, JT ;
Nilsen, R ;
Insel, TR .
BEHAVIORAL NEUROSCIENCE, 1997, 111 (03) :599-605
[38]   Glutamine repeats and neurodegeneration [J].
Zoghbi, HY ;
Orr, HT .
ANNUAL REVIEW OF NEUROSCIENCE, 2000, 23 :217-247