Intramural plasminogen activator inhibitor type-1 and coronary atherosclerosis

被引：92

作者：

Sobel, BE ^{[1
]}

Taatjes, DJ ^{[1
]}

Schneider, DJ ^{[1
]}

机构：

[1] Univ Vermont, Coll Med, Burlington, VT USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2003年 / 23卷 / 11期

关键词：

vulnerable plaques; diabetes; fibrinolysis; atherothrombosis; coronary artery disease;

D O I：

10.1161/01.ATV.0000091250.53231.4D

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Altered expression of plasminogen activator inhibitor type- 1 in vessel walls, reviewed here, might affect coronary atherogenesis. Upregulation might exacerbate vasculopathy by potentiating thrombosis and by inhibiting vascular smooth muscle cell migration, resulting in attenuation of thickness of elaborated fibrous caps implicated in the vulnerability of atheroma to rupture.

引用

收藏

页码：1979 / 1989

页数：11

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