Estrogen receptor- and aromatase-deficient mice provide insight into the roles of estrogen within the ovary and uterus

被引：27

作者：

Rosenfeld, CS

Roberts, RM

Lubahn, DB

机构：

[1] Univ Missouri, Dept Anim Sci, Columbia, MO 65211 USA

[2] Univ Missouri, Dept Biochem, Columbia, MO 65211 USA

[3] Univ Missouri, Dept Vet Pathobiol, Columbia, MO 65211 USA

[4] Univ Missouri, Dept Child Hlth, Columbia, MO 65211 USA

来源：

MOLECULAR REPRODUCTION AND DEVELOPMENT | 2001年 / 59卷 / 03期

关键词：

ERKO; steroid receptor; ovarian follicle; follicular cysts; pathology; granulosa cells; ovulation; corpus luteum; endometrium; uterine hypoplasia;

D O I：

10.1002/mrd.1039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Estrogen receptor (ER)- (alpha, beta, and both alpha and beta) and aromatase (Ar) knockout (KO) mice have been created to assess the biological effects of estrogens. This review article discusses the ovarian and uterine phenotypes of these mice. The data obtained have confirmed some older inferences about how the steroid acts, but have also revealed some unexpected aspects of estrogen action. (C) 2001 Wiley-Liss, Inc.

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页码：336 / 346

页数：11

相关论文

共 77 条

[1] Steroid receptor phylogeny and vertebrate origins [J].

Baker, ME .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1997, 135 (02) :101-107

[2] Androgen receptor, estrogen receptor α, and estrogen receptor β show distinct patterns of expression in forebrain song control nuclei of European starlings [J].

Bernard, DJ ;

Bentley, GE ;

Balthazart, J ;

Turek, FW ;

Ball, GF .

ENDOCRINOLOGY, 1999, 140 (10) :4633-4643

[3] PRESERVATION OF FUNCTIONAL CORPORA LUTEA IN RAT BY ESTROGEN TREATMENT [J].

BOGDANOVE, EM .

ENDOCRINOLOGY, 1966, 79 (05) :1011-+

[4] An age-related ovarian phenotype in mice with targeted disruption of the Cyp 19 (aromatase) gene [J].

Britt, KL ;

Drummond, AE ;

Cox, VA ;

Dyson, M ;

Wreford, NG ;

Jones, MEE ;

Simpson, ER ;

Findlay, JK .

ENDOCRINOLOGY, 2000, 141 (07) :2614-2623

[5] Tissue compartment-specific estrogen receptor-α participation in the mouse uterine epithelial secretory response [J].

Buchanan, DL ;

Setiawan, T ;

Lubahn, DB ;

Taylor, JA ;

Kurita, T ;

Cunha, GR ;

Cooke, PS .

ENDOCRINOLOGY, 1999, 140 (01) :484-491

[6] Estrogen receptor-beta mRNA expression in rat ovary: Down-regulation by gonadotropins [J].

Byers, M ;

Kuiper, GGJM ;

Gustafsson, JA ;

ParkSarge, OK .

MOLECULAR ENDOCRINOLOGY, 1997, 11 (02) :172-182

[7] Evolutionary and functional significance of two CYP19 genes differentially expressed in brain and ovary of goldfish [J].

Callard, GV ;

Tchoudakova, A .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1997, 61 (3-6) :387-392

[8]

Conley A, 1997, J STEROID BIOCHEM, V61, P407, DOI 10.1016/S0960-0760(97)80040-4

[9] Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium [J].

Cooke, PS ;

Buchanan, DL ;

Young, P ;

Setiawan, T ;

Brody, J ;

Korach, KS ;

Taylor, J ;

Lubahn, DB ;

Cunha, GR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (12) :6535-6540

[10] Mechanism of estrogen action:: Lessons from the estrogen receptor-α knockout mouse [J].

Cooke, PS ;

Buchanan, DL ;

Lubahn, DB ;

Cunha, GR .

BIOLOGY OF REPRODUCTION, 1998, 59 (03) :470-475

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