Estrogen receptor- and aromatase-deficient mice provide insight into the roles of estrogen within the ovary and uterus

被引：27

作者：

Rosenfeld, CS

Roberts, RM

Lubahn, DB

机构：

[1] Univ Missouri, Dept Anim Sci, Columbia, MO 65211 USA

[2] Univ Missouri, Dept Biochem, Columbia, MO 65211 USA

[3] Univ Missouri, Dept Vet Pathobiol, Columbia, MO 65211 USA

[4] Univ Missouri, Dept Child Hlth, Columbia, MO 65211 USA

来源：

MOLECULAR REPRODUCTION AND DEVELOPMENT | 2001年 / 59卷 / 03期

关键词：

ERKO; steroid receptor; ovarian follicle; follicular cysts; pathology; granulosa cells; ovulation; corpus luteum; endometrium; uterine hypoplasia;

D O I：

10.1002/mrd.1039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Estrogen receptor (ER)- (alpha, beta, and both alpha and beta) and aromatase (Ar) knockout (KO) mice have been created to assess the biological effects of estrogens. This review article discusses the ovarian and uterine phenotypes of these mice. The data obtained have confirmed some older inferences about how the steroid acts, but have also revealed some unexpected aspects of estrogen action. (C) 2001 Wiley-Liss, Inc.

引用

收藏

页码：336 / 346

页数：11

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