Thiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice

被引：36

作者：

Bermudez, LE

Reynolds, R

Kolonoski, P

Aralar, P

Inderlied, CB

Young, LS

机构：

[1] Oregon State Univ, Coll Vet Med, Dept Biomed Sci, Corvallis, OR 97331 USA

[2] Calif Pacific Med Ctr, Res Inst, Kuzell Inst Arthrit & Infect Dis, San Francisco, CA 94115 USA

[3] So Res Inst, Birmingham, AL 35255 USA

[4] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA

[5] Univ So Calif, Los Angeles, CA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 08期

关键词：

D O I：

10.1128/AAC.47.8.2685-2687.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In vitro screening of thiacetazone derivatives indicated that two derivatives, SRI-286 and SRI-224, inhibited a panel of 25 Mycobacterium avium complex (MAC) isolates at concentrations of 2 mug/ml or lower. In mice, SRI-224 and thiacetazone had no significant activity against the MAC in livers and spleens, but treatment with SRI-286 resulted in significant reduction of bacterial loads in livers and spleens. A combination of SRI-286 and moxifloxacin was significantly more active than single drug regimens in liver and spleen.

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页码：2685 / 2687

页数：3

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