Nuclear inositide signaling:: An appraisal of phospholipase C β1 behavior in myelodysplastic and leukemia cells

被引：9

作者：

Cocco, Lucio ^{[1
]}

Follo, Matilde Y. ^{[1
]}

Faenza, Irene ^{[1
]}

Bavelloni, Alberto ^{[1
]}

Billi, Anna Maria ^{[1
]}

Martelli, Alberto M. ^{[1
]}

Manzoli, Lucia ^{[1
]}

机构：

[1] Univ Bologna, Dept Anat Sci, Cellular Signalling Lab, Via Irnerio 48, I-40126 Bologna, Italy

来源：

ADVANCES IN ENZYME REGULATION, VOL 47 | 2007年 / 47卷

关键词：

D O I：

10.1016/j.advenzreg.2006.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Location impinges on function of some of the main players of nuclear inositol lipid cycle. Here we have discussed the behavior of PI-PLCβ1 in myelodysplastic and cultured leukemia cells. The presence of a cryptic deletion of PI-PLCβ1 gene in high-risk MDS patients is accompanied by altered expression of its mRNA in that the overall decrease of mRNA is characterized by a dramatic decrease of the splicing variant 1a, which is cytosolic and partially nuclear, whilst the splicing variant 1b is still highly represented. This suggests that altered expression of nuclear PI-PLCβ1 could be involved in a disregulation of the cell cycle and have also important effects on cell apoptotic pathways. Moreover, in cultured leukemia cells (Felc) it has been reported by means of a proteomic approach that the splicing factor SRp20 interacts with nuclear PI-PLCβ1 and its expression is modulated by this signaling molecule. All in all, it appears more and more evident that nuclear signaling elicited by PI-PLCβ1 is a key event in the control of cell cycle progression. © 2007 Elsevier Ltd. All rights reserved.

引用

页码：2 / +

页数：4

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