Is poly (ADP-ribose) polymerase involved in bovine placental retention?

被引：4

作者：

Kankofer, M

Guz, L

机构：

[1] Agr Univ, Fac Vet Med, Dept Biochem, PL-20123 Lublin, Poland

[2] Univ Agr, Fac Vet Med, Dept Fis Dis & Biol, PL-20033 Lublin, Poland

来源：

DOMESTIC ANIMAL ENDOCRINOLOGY | 2003年 / 25卷 / 01期

关键词：

poly(ADP-ribose) polymerase (PARP); cow; retained placenta;

D O I：

10.1016/S0739-7240(03)00045-6

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Poly(ADP-ribose) polymerase (PARP) is the enzyme which utilises NAD to synthesise poly(ADPribose) polymers. This process appears in response to DNA lesions. Oxidative stress, which might be involved in bovine placental retention, is the reason for oxidative DNA injury. In this mini-review, the relationship between PARP activity and bovine placental retention is discussed. The results of our experiments on PARP activity in placental tissues showed that the enzyme of 113 kDa and its cleavage products were present in retained as well as released fetal membranes. Western blotting technique showed different intensities in the staining of bands which might suggest different activities of the enzyme. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：61 / 67

页数：7

共 39 条

[1]

ADAMIETZ P, 1984, J BIOL CHEM, V259, P6841

[2] Role of poly(ADP-ribose) polymerase in rapid intracellular acidification induced by alkylating DNA damage [J].