Interleukin-19 Is a Negative Regulator of Innate Immunity and Critical for Colonic Protection

被引：28

作者：

Azuma, Yasu-Taka ^{[1
]}

Matsuo, Yukiko ^{[1
]}

Nakajima, Hidemitsu ^{[1
]}

Yancopoulos, George D. ^{[2
]}

Valenzuela, David M. ^{[2
]}

Murphy, Andrew J. ^{[2
]}

Karow, Margaret ^{[2
]}

Takeuchi, Tadayoshi ^{[1
]}

机构：

[1] Osaka Prefecture Univ, Grad Sch Life & Environm Sci, Div Vet Sci, Lab Vet Pharmacol, Osaka 5988531, Japan

[2] Regeneron Pharmaceut Inc, Tarrytown, NY 10591 USA

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2011年 / 115卷 / 02期

关键词：

interleukin-19; inflammatory bowel disease (IBD); colonic inflammation; macrophages; cytokine; CUTTING EDGE; ANIMAL-MODELS; TNF-ALPHA; T-CELLS; IL-19; RECEPTORS; COLITIS; EXPRESSION; CYTOKINES; IL-20;

D O I：

10.1254/jphs.10R02CR

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The cytokine, interleukin (IL)-19, is a member of the IL-10 family that includes IL-20, IL-22, IL-24, and IL-26. Recent studies have shown that IL-19 is produced by keratinocytes, epithelial cells, macrophages, and B-cells. Little is known about the exact biological role of IL-19 in immunological regulation, although there is an increasing body of data demonstrating that IL-19 is associated with the development of Th2 responses and the pathogenesis of psoriasis. In this review, I shall attempt to discuss current knowledge about the role of IL-19 on macrophages and the potential role in inflammatory bowel disease.

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收藏

页码：105 / 111

页数：7

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