The secretion pathway in filamentous fungi: A biotechnological view

被引:181
作者
Conesa, A [1 ]
Punt, PJ [1 ]
van Luijk, N [1 ]
van den Hondel, CAMJJ [1 ]
机构
[1] TNO, Dept Appl Microbiol & Gene Technol, NL-3700 AJ Zeist, Netherlands
关键词
biotechnology; filamentous fungi; yeast; secretion; heterologous proteins; molecular genetics; unfolded protein response (UPR); chaperones; foldases; GTPases;
D O I
10.1006/fgbi.2001.1276
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The high capacity of the secretion machinery of filamentous fungi has been widely exploited for the production of homologous and heterologous proteins; however, our knowledge of the fungal secretion pathway is still at an early stage. Most of the knowledge comes from models developed in yeast and higher eukaryotes, which have served as reference for the studies on fungal species. In this review we compile the data accumulated in recent years on the molecular basis of fungal secretion, emphasizing the relevance of these data for the biotechnological use of the fungal cell and indicating how this information has been applied in attempts to create improved production strains. We also present recent emerging approaches that promise to provide answers to fundamental questions on the molecular genetics of the fungal secretory pathway. (C) 2001 Academic Press.
引用
收藏
页码:155 / 171
页数:17
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