Antiseptic susceptibility and distribution of antiseptic-resistance genes in methicillin-resistant Staphylococcus aureus

被引：109

作者：

Noguchi, N

Hase, M

Kitta, M

Sasatsu, M

Deguchi, K

Kono, M

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Dept Microbiol, Hachioji, Tokyo 1920392, Japan

[2] Showa Coll Pharmaceut Sci, Dept Microbiol, Machida, Tokyo 194, Japan

[3] Tokyo Clin Res Ctr, Sect Studies, Tokyo 194, Japan

来源：

FEMS MICROBIOLOGY LETTERS | 1999年 / 172卷 / 02期

关键词：

antiseptic resistance gene; Staphylococcus aureus; multidrug efflux pump; nor A;

D O I：

10.1111/j.1574-6968.1999.tb13475.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We examined the antiseptic susceptibilities and distribution of antiseptic-resistance genes qacA and smi in 98 isolates of methicillin-resistant Staphylococcus aureus obtained in 1992. Seventy-one strains were resistant to antiseptics. The qacA and smr genes were detected in 10 and 20 strains, respectively The remaining 41 strains without qacA and smr were divided into two groups that exhibited low-level (n = 22) and high-level (n = 19) resistance to acriflavin. DNA cloning and sequencing suggested that norfloxacin-resistance gene norA was responsible for the high-level resistance to acriflavin. Our results indicated that four or more antiseptic-resistance genes exist in methicillin-resistant S. aureus and that antiseptic-resistant methicillin-resistant S, aureus strains without qacA and sr,li are widely spread in Japan. (C) 1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：247 / 253

页数：7

共 17 条

[1] SELF-TRANSMISSIBLE PLASMIDS IN STAPHYLOCOCCI THAT ENCODE RESISTANCE TO AMINOGLYCOSIDES [J].