Microglia: Housekeeper of the Central Nervous System

被引：229

作者：

Kabba, John Alimamy ^{[1
]}

Xu, Yazhou ^{[1
]}

Christian, Handson ^{[2
]}

Ruan, Wenchen ^{[1
]}

Chenai, Kitchen ^{[3
]}

Xiang, Yun ^{[4
]}

Zhang, Luyong ^{[1
]}

Saavedra, Juan M. ^{[5
]}

Pang, Tao ^{[1
,5
]}

机构：

[1] China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, Jiangsu Key Lab Druggabil Biopharmaceut, State Key Lab Nat Med,Jiangsu Key Lab Drug Screen, 24 Tong Jia Xiang St, Nanjing 210009, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Dept Pharmacol, Nanjing, Jiangsu, Peoples R China

[3] China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China

[4] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Dept Lab Med, Tongji Med Coll, Wuhan 430016, Hubei, Peoples R China

[5] Georgetown Univ, Med Ctr, Dept Physiol & Pharmacol, Washington, DC 20057 USA

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2018年 / 38卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Microglia activation; CNS keeper; Brain aging; Neurons; Oligodendrocytes; Astrocytes; ISCHEMIC BRAIN-INJURY; VASCULAR ENDOTHELIAL-CELLS; AGE-RELATED-CHANGES; SPINAL-CORD-INJURY; DOUBLE-EDGED-SWORD; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; ACTIVATED MICROGLIA; IN-VITRO; DOPAMINERGIC-NEURONS;

D O I：

10.1007/s10571-017-0504-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Microglia, of myeloid origin, play fundamental roles in the control of immune responses and the maintenance of central nervous system homeostasis. These cells, just like peripheral macrophages, may be activated into M1 pro-inflammatory or M2 anti-inflammatory phenotypes by appropriate stimuli. Microglia do not respond in isolation, but form part of complex networks of cells influencing each other. This review addresses the complex interaction of microglia with each cell type in the brain: neurons, astrocytes, cerebrovascular endothelial cells, and oligodendrocytes. We also highlight the participation of microglia in the maintenance of homeostasis in the brain, and their roles in the development and progression of age-related neurodegenerative disorders.

引用

页码：53 / 71

页数：19

共 193 条

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