Synthetic studies toward the microtubule-stabilizing agent laulimalide:: synthesis of the C1-C14 fragment

被引：37

作者：

Nadolski, GT ^{[1
]}

Davidson, BS ^{[1
]}

机构：

[1] Utah State Univ, Dept Chem & Biochem, Logan, UT 84322 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(00)02116-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C-1-C-14 fragment of the paclitaxel-like antimicrotubule agent laulimalide has been synthesized in 15 steps from L-(-)-citronellal. The C-9 chiral center was established using an asymmetric allylation, the dihydropyran ring was prepared through ring-closing metathesis. and the no-methylene was incorporated using Eschenmoser's salt. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：797 / 800

页数：4

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