An enantioselective synthesis of the C2-C16 segment of antitumor macrolide laulimalide

被引：44

作者：

Ghosh, AK ^{[1
]}

Wang, Y ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(00)00158-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective synthesis of the C-2-C-16 Segment of the novel antitumor agent laulimalide is described. The key steps involve a highly diastereoselective allylation, ring-closing olefin metathesis of a homoallylic alcohol derived acrylate ester, a stereoselective anomeric alkylation and an elaboration of an exo-methylene unit by a Julia olefination reaction. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：2319 / 2322

页数：4

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