Comparison of HIV type 1 RNA plasma viremia, p24 antigenemia, and unintegrated DNA as viral load markers in pediatric patients

被引：12

作者：

Bush, CE ^{[1
]}

Donovan, RM ^{[1
]}

Manzor, O ^{[1
]}

Baxa, D ^{[1
]}

Moore, E ^{[1
]}

Cohen, F ^{[1
]}

Saravolatz, LD ^{[1
]}

机构：

[1] CHILDRENS HOSP MICHIGAN,DEPT PEDIAT,DETROIT,MI 48201

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1996年 / 12卷 / 01期

关键词：

D O I：

10.1089/aid.1996.12.11

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Better surrogate markers need to be developed to evaluate therapy in HIV-infected children, This study evaluated plasma RNA, immune complex-dissociated p24 antigenemia, and unintegrated DNA (uDNA) in HIV-infected pediatric patients, Ten children were followed from initiation of nucleoside antiretroviral therapy at intervals up to 24 months, Prior to initiation of therapy, HIV RNA was detected in 10 of 10 patients (median, 76,000 Eq/ml), p24 antigen was detected in 8 of 10 patients (median, 193 pg/ml), and uDNA was detected in 6 of 7 patients (median, 10% uDNA), After 12 months the RNA decreased in all patients and became undetectable in six, In contrast, p24 antigenemia decreased in 6 of 10 patients, remained undetectable in 1, and increased in 3, HIV uDNA decreased in six of six patients and became undetectable in three, There was no overall change in CD4 cell count, Plasma RNA and uDNA levels are both sensitive markers of nucleoside therapy in children; however, they do not covary strongly.

引用

页码：11 / 15

页数：5

共 31 条

[11]

DONOVAN RM, 1994, J ACQ IMMUN DEF SYND, V7, P1237

[12] RAPID DECREASE IN UNINTEGRATED HUMAN-IMMUNODEFICIENCY-VIRUS DNA AFTER THE INITIATION OF NUCLEOSIDE THERAPY [J].