New insights on the involvement of Nerve Growth Factor in allergic inflammation and fibrosis

被引：70

作者：

Micera, A

Puxeddu, I

Aloe, L

Levi-Schaffer, F

机构：

[1] Hebrew Univ Jerusalem, Sch Pharm, Fac Med, Dept Pharmacol, IL-91120 Jerusalem, Israel

[2] CNR, Inst Neurobiol & Mol Med, Rome, Italy

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2003年 / 14卷 / 05期

关键词：

allergy; eosinophils; mast cells; myofibroblasts; NGF; inflammation; fibrosis;

D O I：

10.1016/S1359-6101(03)00047-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nerve Growth Factor (NGF), that was originally discovered for its properties of stimulating growth and differentiation of neurons, is now also considered responsible for several activities in the immune system and beyond. Mast cells and eosinophils, key cells of allergic inflammation, are a source of NGF and are influenced by it. These observations have prompted studies on NGF in allergy and tissue repair. Recent evidences link NGF and these two processes. While NGF is clearly a new tool in the management of untreatable ulcers, its role in allergic inflammation, although appearing to be pro-inflammatory, is still not clearly defined. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：369 / 374

页数：6

共 65 条

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