New insights on the involvement of Nerve Growth Factor in allergic inflammation and fibrosis

被引：70

作者：

Micera, A

Puxeddu, I

Aloe, L

Levi-Schaffer, F

机构：

[1] Hebrew Univ Jerusalem, Sch Pharm, Fac Med, Dept Pharmacol, IL-91120 Jerusalem, Israel

[2] CNR, Inst Neurobiol & Mol Med, Rome, Italy

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2003年 / 14卷 / 05期

关键词：

allergy; eosinophils; mast cells; myofibroblasts; NGF; inflammation; fibrosis;

D O I：

10.1016/S1359-6101(03)00047-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nerve Growth Factor (NGF), that was originally discovered for its properties of stimulating growth and differentiation of neurons, is now also considered responsible for several activities in the immune system and beyond. Mast cells and eosinophils, key cells of allergic inflammation, are a source of NGF and are influenced by it. These observations have prompted studies on NGF in allergy and tissue repair. Recent evidences link NGF and these two processes. While NGF is clearly a new tool in the management of untreatable ulcers, its role in allergic inflammation, although appearing to be pro-inflammatory, is still not clearly defined. (C) 2003 Elsevier Ltd. All rights reserved.

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收藏

页码：369 / 374

页数：6

相关论文

共 65 条

[11] Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factors [J].

Calzà, L ;

Giardino, L ;

Giuliani, A ;

Aloe, L ;

Levi-Montalcini, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (07) :4160-4165

[12] Nerve growth factor-endothelial cell interaction leads to angiogenesis in vitro and in vivo [J].

Cantarella, G ;

Lempereur, L ;

Presta, M ;

Ribatti, D ;

Lombardo, G ;

Lazarovici, P ;

Zappalà, G ;

Pafumi, C ;

Bernardini, R .

FASEB JOURNAL, 2002, 16 (08) :1307-+

[13] Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75 [J].

CasacciaBonnefil, P ;

Carter, BD ;

Dobrowsky, RT ;

Chao, MV .

NATURE, 1996, 383 (6602) :716-719

[14] Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TRKA and requires the common neurotrophin receptor p75 [J].

Culmsee, C ;

Gerling, N ;

Lehmann, M ;

Nikolova-Karakashian, M ;

Prehn, JHM ;

Mattson, MP ;

Krieglstein, J .

NEUROSCIENCE, 2002, 115 (04) :1089-1108

[15] Nerve growth factor induces a neurokinin-1 receptor-mediated airway hyperresponsiveness in guinea pigs [J].

de Vries, A ;

Dessing, MC ;

Engels, F ;

Henricks, PAJ ;

Nijkamp, FP .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 159 (05) :1541-1544

[16] Antibodies directed against nerve growth factor inhibit the acute bronchoconstriction due to allergen challenge in guinea-pigs [J].

De Vries, A ;

Engels, F ;

Henricks, PAJ ;

Leusink-Muis, T ;

Fischer, A ;

Nijkamp, FP .

CLINICAL AND EXPERIMENTAL ALLERGY, 2002, 32 (02) :325-328

[17] MAPPING THE HUMAN AMYLASE GENE-CLUSTER ON THE PROXIMAL SHORT ARM OF CHROMOSOME-1 USING A HIGHLY INFORMATIVE (CA)N REPEAT [J].

DRACOPOLI, NC ;

MEISLER, MH .

GENOMICS, 1990, 7 (01) :97-102

[18] The cytoplasmic and transmembrane domains of the p75 and Trk a receptors regulate high affinity binding to nerve growth factor [J].

Esposito, D ;

Patel, P ;

Stephens, RM ;

Perez, P ;

Chao, MV ;

Kaplan, DR ;

Hempstead, BL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (35) :32687-32695

[19] Nerve growth factor and its high-affinity receptor in chronic pancreatitis [J].

Friess, H ;

Zhu, ZW ;

di Mola, FF ;

Kulli, C ;

Graber, HU ;

Andren-Sandberg, Å ;

Zimmermann, A ;

Korc, M ;

Reinshagen, M ;

Büchler, MW .

ANNALS OF SURGERY, 1999, 230 (05) :615-624

[20] Human mast cells stimulate fibroblast proliferation, collagen synthesis and lattice contraction: a direct role for mast cells in skin fibrosis [J].

Garbuzenko, E ;

Nagler, A ;

Pickholtz, D ;

Gillery, P ;

Reich, R ;

Maquart, FX ;

Levi-Schaffer, F .

CLINICAL AND EXPERIMENTAL ALLERGY, 2002, 32 (02) :237-246

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