Impaired pulmonary oxygen uptake kinetics and reduced peak aerobic power during small muscle mass exercise in heart transplant recipients

被引:21
作者
Jendzjowsky, Nicholas G.
Tomczak, Corey R.
Lawrance, Richard
Taylor, Dylan A.
Tymchak, Wayne J.
Riess, Kenneth J.
Warburton, Darren E. R.
Haykowsky, Mark J.
机构
[1] Univ Alberta, Cardiovasc Therapeut Excercise Lab, Fac Rehabil Med, Edmonton, AB T6G 2G4, Canada
[2] Univ Alberta, Div Cardiol, Edmonton, AB, Canada
[3] Univ British Columbia, Fac Med, Cardiovasc Physiol & Rehabil Lab, Vancouver, BC, Canada
关键词
D O I
10.1152/japplphysiol.00725.2007
中图分类号
Q4 [生理学];
学科分类号
071003 [生理学];
摘要
We examined peak and reserve cardiovascular function and skeletal muscle oxygenation during unilateral knee extension ( ULKE) exercise in five heart transplant recipients ( HTR, mean +/- SE; age: 53 +/- 3 years; years posttransplant: 6 +/- 4) and five age- and body mass- matched healthy controls ( CON). Pulmonary oxygen uptake (VO2p), heart rate ( HR), stroke volume ( SV), cardiac output ( Q.), and skeletal muscle deoxygenation ( HHb) kinetics were assessed during moderate-intensity ULKE exercise. Peak exercise and reserve Vo(2p), Q, and systemic arterial- venous oxygen difference (a-vO(2diff)) were 23 - 52% lower ( P < 0.05) in HTR. The reduced Q. and a- vO(2diff) reserves were associated with lower HR and HHb reserves, respectively. The phase II VO2p time delay was greater ( HTR: 38 +/- 2 vs. CON: 25 +/- 1 s, P < 0.05), while time constants for phase II VO2p ( HTR: 54 +/- 8 vs. CON: 31 +/- 3 s), Q. ( HTR: 66 +/- 8 vs. CON: 28 +/- 4 s), and HHb ( HTR: 27 +/- 5 vs. CON: 13 +/- 3 s) were significantly slower in HTR. The HR half- time was slower in HTR ( 113 +/- 21 s) vs. CON ( 21 +/- 2 s, P < 0.05); however, no significant difference was found between groups for SV kinetics ( HTR: 39 +/- 8 s vs. CON 31 +/- 6 s). The lower peak VO2p and prolonged VO2p kinetics in HTR were secondary to impairments in both cardiovascular and skeletal muscle function that result in reduced oxygen delivery and utilization by the active muscles.
引用
收藏
页码:1722 / 1727
页数:6
相关论文
共 30 条
[1]
MAXIMAL PERFUSION OF SKELETAL-MUSCLE IN MAN [J].
ANDERSEN, P ;
SALTIN, B .
JOURNAL OF PHYSIOLOGY-LONDON, 1985, 366 (SEP) :233-249
[2]
A NEW METHOD FOR DETECTING ANAEROBIC THRESHOLD BY GAS-EXCHANGE [J].
BEAVER, WL ;
WASSERMAN, K ;
WHIPP, BJ .
JOURNAL OF APPLIED PHYSIOLOGY, 1986, 60 (06) :2020-2027
[3]
Comparison of impedance cardiography with thermodilution and direct fick methods for noninvasive measurement of stroke volume and cardiac output during incremental exercise in patients with ischemic cardiomyopathy [J].
Belardinelli, R ;
Ciampani, N ;
Costantini, C ;
Blandini, A ;
Purcaro, A .
AMERICAN JOURNAL OF CARDIOLOGY, 1996, 77 (15) :1293-1301
[4]
Stroke volume equation for impedance cardiography [J].
Bernstein, DP ;
Lemmens, HJM .
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 2005, 43 (04) :443-450
[5]
Serial assessment of peak (V) over dot O2 and (V) over dot O2 kinetics early after heart transplantation [J].
Borrelli, E ;
Pogliaghi, S ;
Molinello, A ;
Diciolla, F ;
Maccherini, M ;
Grassi, B .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2003, 35 (11) :1798-1804
[6]
Monitoring tissue oxygen availability with near infrared spectroscopy (NIRS) in health and disease [J].
Boushel, R ;
Langberg, H ;
Olesen, J ;
Gonzales-Alonzo, J ;
Bülow, J ;
Kjær, M .
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, 2001, 11 (04) :213-222
[7]
Bussieres LM, 1995, J HEART LUNG TRANSPL, V14, P1073
[8]
Changes in skeletal muscle morphology and biochemistry after cardiac transplantation [J].
Bussieres, LM ;
Pflugfelder, PW ;
Taylor, AW ;
Noble, EG ;
Kostuk, WJ .
AMERICAN JOURNAL OF CARDIOLOGY, 1997, 79 (05) :630-634
[9]
GAS-EXCHANGE AND METABOLIC TRANSIENTS IN HEART-TRANSPLANT RECIPIENTS [J].
CERRETELLI, P ;
GRASSI, B ;
COLOMBINI, A ;
CARU, B ;
MARCONI, C .
RESPIRATION PHYSIOLOGY, 1988, 74 (03) :355-371
[10]
GAS-EXCHANGE KINETICS IN HEART-TRANSPLANT RECIPIENTS [J].
CERRETELLI, P ;
MARCONI, C ;
MEYER, M ;
FERRETTI, G ;
GRASSI, B .
CHEST, 1992, 101 (05) :S199-S205