Cells of the synovium in rheumatoid arthritis -: Macrophages

被引：255

作者：

Kinne, Raimund W. ^{[1
]}

Stuhlmueller, Bruno ^{[2
]}

Burmester, Gerd-R ^{[2
]}

机构：

[1] Univ Clin, Dept Orthoped, Expt Rheumatol Unit, D-07607 Jena, Germany

[2] Humboldt Univ, Charite Univ Hosp, Dept Rheumatol & Clin Immunol, D-10117 Berlin, Germany

来源：

ARTHRITIS RESEARCH & THERAPY | 2007年 / 9卷 / 06期

关键词：

D O I：

10.1186/ar2333

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The multitude and abundance of macrophage-derived mediators in rheumatoid arthritis and their paracrine/autocrine effects identify macrophages as local and systemic amplifiers of disease. Although uncovering the etiology of rheumatoid arthritis remains the ultimate means to silence the pathogenetic process, efforts in understanding how activated macrophages influence disease have led to optimization strategies to selectively target macrophages by agents tailored to specific features of macrophage activation. This approach has two advantages: ( a) striking the cell population that mediates/amplifies most of the irreversible tissue destruction and (b) sparing other cells that have no (or only marginal) effects on joint damage.

引用

页数：16

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