Recombination between sequences of hepatitis B virus from different genotypes

被引：113

作者：

Bollyky, PL ^{[1
]}

Rambaut, A ^{[1
]}

Harvey, PH ^{[1
]}

Holmes, EC ^{[1
]}

机构：

[1] UNIV OXFORD,DEPT ZOOL,WELLCOME CTR EPIDEMIOL INFECT DIS,OXFORD OX1 3PS,ENGLAND

来源：

JOURNAL OF MOLECULAR EVOLUTION | 1996年 / 42卷 / 02期

基金：

英国惠康基金;

关键词：

hepatitis B virus; recombination; phylogeny; coinfection; genotypes; antigenic subtypes;

D O I：

10.1007/BF02198834

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A comparison of 25 hepatitis B virus (HBV) isolates for which complete genome sequences are available revealed two that occupied different positions in phylogenetic trees reconstructed from different open reading frames. Further analysis indicated that this incongruence was the result of recombination between viruses of different genomic and antigenic types. Both putative recombinants originated from geographic regions where multiple genotypes are known to cocirculate. A search of the sequence databases showed evidence of similar intergenotypic recombinants. These observations indicate that recombination between divergent strains may represent an important source of genetic variation in HBV.

引用

页码：97 / 102

页数：6

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