SIRT3 and cancer: Tumor promoter or suppressor?

被引：157

作者：

Alhazzazi, Turki Y. ^{[1
]}

Kamarajan, Pachiyappan ^{[1
]}

Verdin, Eric ^{[2
]}

Kapila, Yvonne L. ^{[1
]}

机构：

[1] Univ Michigan, Sch Dent, Dept Periodont & Oral Med, Ann Arbor, MI 48109 USA

[2] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, San Francisco, CA 94158 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2011年 / 1816卷 / 01期

关键词：

Sirtuin-3; SIRT3; Cancer; Tumor promoter; Tumor suppressor; HISTONE DEACETYLASE INHIBITORS; IN-SITU HYBRIDIZATION; BCL-2 FAMILY PROTEINS; FATTY-ACID OXIDATION; CARCINOMA CELL-LINES; CALORIE RESTRICTION; SIRT3-MEDIATED DEACETYLATION; CHROMOSOMAL ORGANIZATION; INSULIN-SECRETION; DOWN-REGULATION;

D O I：

10.1016/j.bbcan.2011.04.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sirtuins (SIRT1-7), the mammalian homologues of the Sir2 gene in yeast, have emerging roles in age-related diseases, such as cardiac hypertrophy, diabetes, obesity, and cancer. However, the role of several sirtuin family members, including SIRT1 and SIRT3, in cancer has been controversial. The aim of this review is to explore and discuss the seemingly dichotomous role of SIRT3 in cancer biology with particular emphasis on its potential role as a tumor promoter and tumor suppressor. This review will also discuss the potential role of SIRT3 as a novel therapeutic target to treat cancer. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：80 / 88

页数：9

共 130 条

[1] Rational development of histone deacetylase inhibitors as anticancer agents: A review
Acharya, MR
Sparreboom, A
Venitz, J
Figg, WD
[J]. MOLECULAR PHARMACOLOGY, 2005, 68 (04) : 917 - 932
[2] A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
Ahn, Bong-Hyun
Kim, Hyun-Seok
Song, Shiwei
Lee, In Hye
Liu, Jie
Vassilopoulos, Athanassios
Deng, Chu-Xia
Finkel, Toren
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (38) : 14447 - 14452
[3] Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase
Ahuja, Nidhi
Schwer, Bjoern
Carobbio, Stefania
Waltregny, David
North, Brian J.
Castronovo, Vincenzo
Maechler, Pierre
Verdin, Eric
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (46) : 33583 - 33592
[4] Sirtuin-3 (SIRT3), a Novel Potential Therapeutic Target for Oral Cancer
Alhazzazi, Turki Y.
Kamarajan, Pachiyappan
Joo, Nam
Huang, Jing-Yi
Verdin, Eric
D'Silva, Nisha J.
Kapila, Yvonne L.
[J]. CANCER, 2011, 117 (08) : 1670 - 1678
[5] SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways
Allison, Simon J.
Milner, Jo
[J]. CELL CYCLE, 2007, 6 (21) : 2669 - 2677
[6] Insulin secretion: SIRT4 gets in on the act
Argmann, Carmen
Auwerx, Johan
[J]. CELL, 2006, 126 (05) : 837 - 839
[7] Altered sirtuin expression is associated with node-positive breast cancer
Ashraf, N.
Zino, S.
MacIntyre, A.
Kingsmore, D.
Payne, A. P.
George, W. D.
Shiels, P. G.
[J]. BRITISH JOURNAL OF CANCER, 2006, 95 (08) : 1056 - 1061
[8] Resveratrol: A review of preclinical studies for human cancer prevention
Athar, Mohammad
Back, Jung Ho
Tang, Xmwel
Kim, Kwang Ho
Kopelovich, Levy
Bickers, David R.
Kim, Arianna L.
[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 2007, 224 (03) : 274 - 283
[9] Role of oxidative/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation
Azad, Neelam
Iyer, Anand
Vallyathan, Val
Wang, Liying
Castranova, Vincent
Stehlik, Christian
Rojanasakul, Yon
[J]. OXIDATIVE/NITROSATIVE STRESS AND DISEASE, 2010, 1203 : 1 - 6
[10] Nitric Oxide-Mediated Bcl-2 Stabilization Potentiates Malignant Transformation of Human Lung Epithelial Cells
Azad, Neelam
Iyer, Anand Krishnan V.
Wang, Liying
Lu, Yongju
Medan, Djordje
Castranova, Vincent
Rojanasakul, Yon
[J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2010, 42 (05) : 578 - 585

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