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SIRT3 and cancer: Tumor promoter or suppressor?

被引：157
作者：
Alhazzazi, Turki Y. [1 ]
Kamarajan, Pachiyappan [1 ]
Verdin, Eric [2 ]
Kapila, Yvonne L. [1 ]
机构：
[1] Univ Michigan, Sch Dent, Dept Periodont & Oral Med, Ann Arbor, MI 48109 USA
[2] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, San Francisco, CA 94158 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2011年 / 1816卷 / 01期
关键词：
Sirtuin-3; SIRT3; Cancer; Tumor promoter; Tumor suppressor; HISTONE DEACETYLASE INHIBITORS; IN-SITU HYBRIDIZATION; BCL-2 FAMILY PROTEINS; FATTY-ACID OXIDATION; CARCINOMA CELL-LINES; CALORIE RESTRICTION; SIRT3-MEDIATED DEACETYLATION; CHROMOSOMAL ORGANIZATION; INSULIN-SECRETION; DOWN-REGULATION;
D O I：
10.1016/j.bbcan.2011.04.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sirtuins (SIRT1-7), the mammalian homologues of the Sir2 gene in yeast, have emerging roles in age-related diseases, such as cardiac hypertrophy, diabetes, obesity, and cancer. However, the role of several sirtuin family members, including SIRT1 and SIRT3, in cancer has been controversial. The aim of this review is to explore and discuss the seemingly dichotomous role of SIRT3 in cancer biology with particular emphasis on its potential role as a tumor promoter and tumor suppressor. This review will also discuss the potential role of SIRT3 as a novel therapeutic target to treat cancer. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：80 / 88
页数：9
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共 130 条
  • [61] SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
    Kim, Hyun-Seok
    Patel, Krish
    Muldoon-Jacobs, Kristi
    Bisht, Kheem S.
    Aykin-Burns, Nukhet
    Pennington, J. Daniel
    van der Meer, Riet
    Nguyen, Phuongmai
    Savage, Jason
    Owens, Kjerstin M.
    Vassilopoulos, Athanassios
    Ozden, Ozkan
    Park, Seong-Hoon
    Singh, Keshav K.
    Abdulkadir, Sarki A.
    Spitz, Douglas R.
    Deng, Chu-Xia
    Gius, David
    [J]. CANCER CELL, 2010, 17 (01) : 41 - 52
  • [62] Tissue Specific Diurnal Rhythms of Metabolites and Their Regulation during Herbivore Attack in a Native Tobacco, Nicotiana attenuata
    Kim, Sang-Gyu
    Yon, Felipe
    Gaquerel, Emmanuel
    Gulati, Jyotasana
    Baldwin, Ian T.
    [J]. PLOS ONE, 2011, 6 (10):
  • [63] Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis
    Kong, Xingxing
    Wang, Rui
    Xue, Yuan
    Liu, Xiaojun
    Zhang, Huabing
    Chen, Yong
    Fang, Fude
    Chang, Yongsheng
    [J]. PLOS ONE, 2010, 5 (07):
  • [64] Mitochondrial function as a determinant of life span
    Lanza, Ian R.
    Nair, K. Sreekumaran
    [J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2010, 459 (02): : 277 - 289
  • [65] Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins
    Law, Ivy K. M.
    Liu, Ling
    Xu, Aimin
    Lam, Karen S. L.
    Vanhoutte, Paul M.
    Che, Chi-Ming
    Leung, Priscilla T. Y.
    Wang, Yu
    [J]. PROTEOMICS, 2009, 9 (09) : 2444 - 2456
  • [66] Reactive oxygen species (ROS) control the expression of Bcl-2 family proteins by regulating their phosphorylation and ubiquitination
    Li, DC
    Ueta, E
    Kimura, T
    Yamamoto, T
    Osaki, T
    [J]. CANCER SCIENCE, 2004, 95 (08) : 644 - 650
  • [67] p53-Induced Growth Arrest Is Regulated by the Mitochondrial SirT3 Deacetylase
    Li, SiDe
    Banck, Michaela
    Mujtaba, Shiraz
    Zhou, Ming-Ming
    Sugrue, Mary M.
    Walsh, Martin J.
    [J]. PLOS ONE, 2010, 5 (05):
  • [68] Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer
    Liu, Y.
    [J]. PROSTATE CANCER AND PROSTATIC DISEASES, 2006, 9 (03) : 230 - 234
  • [69] SIRT6 in DNA repair, metabolism and ageing
    Lombard, D. B.
    Schwer, B.
    Alt, F. W.
    Mostoslavsky, R.
    [J]. JOURNAL OF INTERNAL MEDICINE, 2008, 263 (02) : 128 - 141
  • [70] Mammalian sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
    Lombard, David B.
    Alt, Frederick W.
    Cheng, Hwei-Ling
    Bunkenborg, Jakob
    Streeper, Ryan S.
    Mostoslavsky, Raul
    Kim, Jennifer
    Yancopoulos, George
    Valenzuela, David
    Murphy, Andrew
    Yang, Yinhua
    Chen, Yaohui
    Hirschey, Matthew D.
    Bronson, Roderick T.
    Haigis, Marcia
    Guarente, Leonard P.
    Farese, Robert V., Jr.
    Weissman, Sherman
    Verdin, Eric
    Schwer, Bjoern
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (24) : 8807 - 8814
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