Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

被引：2237

作者：

Oppmann, B ^{[1
]}

Lesley, R ^{[1
]}

Blom, B ^{[1
]}

Timans, JC ^{[1
]}

Xu, YM ^{[1
]}

Hunte, B ^{[1
]}

Vega, F ^{[1
]}

Yu, N ^{[1
]}

Wang, J ^{[1
]}

Singh, K ^{[1
]}

Zonin, F ^{[1
]}

Vaisberg, E ^{[1
]}

Churakova, T ^{[1
]}

Liu, MR ^{[1
]}

Gorman, D ^{[1
]}

Wagner, J ^{[1
]}

Zurawski, S ^{[1
]}

Liu, YJ ^{[1
]}

Abrams, JS ^{[1
]}

Moore, KW ^{[1
]}

Rennick, D ^{[1
]}

de Waal-Malefyt, R ^{[1
]}

Hannum, C ^{[1
]}

Bazan, JF ^{[1
]}

Kastelein, RA ^{[1
]}

机构：

[1] DNAX Res Inst Mol & Cellular Biol Inc, Palo Alto, CA 94304 USA

来源：

IMMUNITY | 2000年 / 13卷 / 05期

关键词：

D O I：

10.1016/S1074-7613(00)00070-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A novel sequence discovered in a computational screen appears distantly related to the p35 subunit of IL-12. This factor, which we term p19, shows no biological activity by itself; instead, it combines with the p40 subunit of IL-12 to form a novel, biologically active, composite cytokine, which we term IL-23. Activated dendritic cells secrete detectable levels of this complex. IL-23 binds to IL-12R beta1 but fails to engage IL-12R beta2; nonetheless, IL-23 activates Stat4 in PHA blast T cells. IL-23 induces strong proliferation of mouse memory (CD4(+)CD45Rb(low))T cells, a unique activity of IL-23 as IL-12 has no effect on this cell population. Similar to IL-12, human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory)T cells.

引用

页码：715 / 725

页数：11

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