Respiratory epithelial cells orchestrate pulmonary innate immunity

被引：527

作者：

Whitsett, Jeffrey A. ^{[1
,2
,3
]}

Alenghat, Theresa ^{[3
,4
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Perinatal Inst, Div Neonatol, Div Perinatal Biol, Cincinnati, OH 45229 USA

[2] Cincinnati Childrens Hosp Med Ctr, Perinatal Inst, Div Pulm Biol, Cincinnati, OH 45229 USA

[3] Univ Cincinnati, Coll Med, Cincinnati, OH USA

[4] Cincinnati Childrens Hosp Med Ctr, Div Immunol, Cincinnati, OH 45229 USA

来源：

NATURE IMMUNOLOGY | 2015年 / 16卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SURFACTANT PROTEIN-C; ENDOPLASMIC-RETICULUM STRESS; TOLL-LIKE RECEPTORS; PRIMARY CILIARY DYSKINESIA; HOUSE-DUST MITE; ANTIMICROBIAL ACTIVITY; ALLERGIC INFLAMMATION; AIRWAY EPITHELIUM; BARRIER FUNCTION; GM-CSF;

D O I：

10.1038/ni.3045

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The epithelial surfaces of the lungs are in direct contact with the environment and are subjected to dynamic physical forces as airway tubes and alveoli are stretched and compressed during ventilation. Mucociliary clearance in conducting airways, reduction of surface tension in the alveoli, and maintenance of near sterility have been accommodated by the evolution of a multi-tiered innate host-defense system. The biophysical nature of pulmonary host defenses are integrated with the ability of respiratory epithelial cells to respond to and 'instruct' the professional immune system to protect the lungs from infection and injury.

引用

页码：27 / 35

页数：9

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