The nematode Caenorhabditis elegans as a model to study the roles of proteoglycans

被引：9

作者：

Berninsone, PM ^{[1
]}

Hirschberg, CB ^{[1
]}

机构：

[1] Boston Univ, Sch Dent Med, Dept Mol & Cell Biol, Boston, MA 02118 USA

来源：

GLYCOCONJUGATE JOURNAL | 2002年 / 19卷 / 4-5期

关键词：

Caenorhabditis elegans; development; glycoconjugates; proteoglycans; Golgi apparatus;

D O I：

10.1023/A:1025364820713

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nematode Caenorhabditis elegans is a powerful animal model for exploring the genetic basis of metazoan development. Recent genetic and biochemical studies have revealed that the molecular machinery of glycosaminoglycan (GAG) biosynthesis and modification is highly conserved between C. elegans and mammals. In addition, genetic studies have implicated GAGs in vulval morphogenesis and zygotic cytokinesis. The extensive knowledge of C. elegans biology, including its elucidated cell lineage, together with the completed and well annotated DNA sequence and availability of reverse genetic tools, provide a platform for studying the functions of proteoglycans and their GAG modification.

引用

页码：325 / 330

页数：6

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