The TB structural genomics consortium:: a resource for Mycobacterium tuberculosis biology

被引：91

作者：

Terwilliger, TC

Park, MS

Waldo, GS

Berendzen, J

Hung, LW

Kim, CY

Smith, CV

Sacchettini, JC

Bellinzoni, M

Bossi, R

De Rossi, E

Mattevi, A

Milano, A

Riccardi, G

Rizzi, M

Roberts, MM

Coker, AR

Fossati, G

Mascagni, P

Coates, ARM

Wood, SP

Goulding, CW

Apostol, MI

Anderson, DH

Gill, HS

Eisenberg, DS

Taneja, B

Mande, S

Pohl, E

Lamzin, V

Tucker, P

Wilmanns, M

Colovos, C

Meyer-Klaucke, W

Munro, AW

McLean, KJ

Marshall, KR

Leys, D

Yang, JK

Yoon, HJ

Lee, BI

Lee, MG

Kwak, JE

Han, BW

Lee, JY

Baek, SH

Suh, SW

Komen, MM

Arcus, VL

Baker, EN

机构：

[1] Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87545 USA

[2] Los Alamos Natl Lab, Div Phys, Los Alamos, NM 87545 USA

[3] Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA

[4] Univ Pavia, Dept Genet & Microbiol, I-27100 Pavia, Italy

[5] St George Hosp, Sch Med, Dept Cellular & Mol Med, London SW17 0RE, England

[6] Univ Southampton, Sch Biol Sci, Div Biochem & Mol Biol, Southampton SO16 7PX, Hants, England

[7] Italfarmaco Res Ctr, I-20092 Milan, Italy

[8] Univ Calif Los Angeles, Inst Mol Biol, Howard Hughes Med Inst, DOE Lab Struct Biol, Los Angeles, CA 90095 USA

[9] Ctr DNA Fingerprinting & Diagnost, Hyderabad 500076, Andhra Pradesh, India

[10] DESY, EMBL Hamburg, D-22603 Hamburg, Germany

[11] Univ Leicester, Dept Biochem, Leicester LE1 7RH, Leics, England

[12] Seoul Natl Univ, Sch Chem & Mol Engn, Struct Prote Lab, Seoul 151742, South Korea

[13] Univ Auckland, Sch Biol Sci, Struct Biol Lab, Auckland 1, New Zealand

[14] Yeshiva Univ Albert Einstein Coll Med, Sch Med, Bronx, NY 10461 USA

[15] Univ Calif Berkeley, Berkeley, CA 94720 USA

[16] Lawrence Livermore Natl Lab, Livermore, CA 94551 USA

来源：

TUBERCULOSIS | 2003年 / 83卷 / 04期

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

protein structure; X-ray crystallography; structural genomics; mycobacterium tuberculosis; drug discovery;

D O I：

10.1016/S1472-9792(03)00051-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The TB Structural Genomics Consortium is an organization devoted to encouraging, coordinating, and facilitating the determination and analysis of structures of proteins from Mycobacterium tuberculosis. The Consortium members hope to work together with other A tuberculosis researchers to identify A tuberculosis proteins for which structural information could provide important biological information, to analyze and interpret structures of A tuberculosis proteins, and to work collaboratively to test ideas about A tuberculosis protein function that are suggested by structure or related to structural information. This review describes the TB Structural Genomics Consortium and some of the proteins for which the Consortium is in the progress of determining three-dimensional structures. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：223 / 249

页数：27

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[81] Biochemical and genetic data suggest that InhA is not the primary target for activated isoniazid in Mycobacterium tuberculosis [J].