Azaindole derivatives with high affinity for the dopamine D4 receptor:: Synthesis, ligand binding studies and comparison of molecular electrostatic potential maps

被引：110

作者：

Löber, S ^{[1
]}

Hübner, H ^{[1
]}

Gmeiner, P ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Inst Pharm & Lebensmittelchem, D-91052 Erlangen, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(98)00692-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Piperazinylmethyl substituted pyrazolo[1,5-a]pyridines and related heterocycles were synthesized and found to recognize selectively the dopamine D4 receptor. For the most potent derivative 10d a Ki value of 2.0 nM was observed. SAR studies including the comparison of molecular isopotential surfaces were performed. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：97 / 102

页数：6

共 23 条

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