Cell death induced by a I-131-labeled monoclonal antibody in ovarian cancer multicell spheroids

被引：8

作者：

Filippovich, IV ^{[1
]}

Sorokina, N ^{[1
]}

Robillard, N ^{[1
]}

FaivreChauvet, A ^{[1
]}

Bardies, M ^{[1
]}

Chatal, JF ^{[1
]}

机构：

[1] INST BIOL,INSERM U211,F-44035 NANTES 01,FRANCE

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1996年 / 23卷 / 05期

关键词：

multicell spheroids; labeled antibodies; apoptosis; necrosis;

D O I：

10.1016/0969-8051(96)00059-5

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Treatment of OVCAR-3 spheroids with I-131-OC125 monoclonal antibody produced a decrease in spheroid volume and a concomitant rise in necrotic cell number. No increase in apoptotic cell number was observed during incubation of spheroids with the labeled antibody. Necrosis began early, reaching a maximum after 3 Gy of accumulated dose delivered at a dose rate of 1.8 cGy/h. Higher accumulated doses induced necrosis for longer incubation times. Thus, dose rate and time are both determinants of ultimate radiation effects when spheroids are incubated with labeled antibodies, although dose rate is the most important factor.

引用

页码：623 / 626

页数：4

共 13 条

[1] USE OF MULTICELL SPHEROIDS OF OVARIAN-CARCINOMA AS AN INTRAPERITONEAL RADIO-IMMUNOTHERAPY MODEL - UPTAKE, RETENTION KINETICS AND DOSIMETRIC EVALUATION [J].