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Mammalian centromeres: DNA sequence, protein composition, and role in cell cycle progression

被引：63
作者：
Craig, JM [1 ]
Earnshaw, WC [1 ]
Vagnarelli, P [1 ]
机构：
[1] Univ Edinburgh, Inst Cell & Mol Biol, Edinburgh EH9 3JR, Midlothian, Scotland
来源：
EXPERIMENTAL CELL RESEARCH | 1999年 / 246卷 / 02期
基金：
英国惠康基金;
关键词：
D O I：
10.1006/excr.1998.4278
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The centromere is a specialized region of the eukaryotic chromosome that is responsible for directing chromosome movements in mitosis and for coordinating the progression of mitotic events at the crucial transition between metaphase and anaphase. In this review, we will focus on recent advances in the understanding of centromere composition at the protein and DNA level and of the role of centromeres in sister-chromatid cohesion and mitotic checkpoint control. (C) 1999 Academic Press.
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收藏
页码：249 / 262
页数：14
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