GSTM1 polymorphism and oral squamous cell carcinoma

被引：28

作者：

Drummond, SN

De Marco, L

Noronha, JCM

Gomez, RS

机构：

[1] Fac Odontol, Dept Patol & Cirurg, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, BR-31270901 Belo Horizonte, MG, Brazil

来源：

ORAL ONCOLOGY | 2004年 / 40卷 / 01期

关键词：

oral squamous cell carcinoma; GSTM1; polymorphism;

D O I：

10.1016/S1368-8375(03)00132-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the frequency of the GSTM1 genotypes in 70 Brazilian patients with oral squamous cell carcinoma (OSCC) and 82 age-sex matched controls. The GSTM1 genotypes were studied by PCR-based methods. The frequency of mate patients with OSCC and null. for the GSTM1 (70.5%) was statistically different from the mate patients from the control group (48.5%) (Odds Ratio, OR=2.53, 95% Cl=1.22-5.24, P<0.05). The frequency of the GSTM1 nut[ genotype (0/0) in the group with OSCC (65.7%) was statistically different from the controls (48.7%) (OR=2.01, 95% Cl=1.04-3.88, P<0.05). The prevalence of GSTM1 deficiency (null) was significantly higher for patients with oral cancer of the floor of the mouth (OR=3.67, 95% Cl=1.11-12.11, P<0.05). In conclusion, the GSTM1 null genotype may increase the risk for OSCC development. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：52 / 55

页数：4

共 20 条

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