Stromal derived growth factor-1alpha as a beacon for stem cell homing in development and injury

被引：22

作者：

Claps, CM

Corcoran, KE

Ch, KJ

Rameshwar, P

机构：

[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Med, Div Hematol & Oncol, Newark, NJ 07103 USA

[2] Univ Med & Dent New Jersey, Grad Sch Biomed Sci, Newark, NJ 07103 USA

[3] Korea Univ, Coll Hlth Sci, Dept Clin Lab Sci, Seoul, South Korea

来源：

CURRENT NEUROVASCULAR RESEARCH | 2005年 / 2卷 / 04期

关键词：

stromal derived growth factor-1alpha; CXCR-4; stem cells; chemokines; cancer; hematopoiesis; neural repair;

D O I：

10.2174/156720205774322593

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This review extrapolates the functions of SDF-1 alpha and its receptor, CXCR4, as regulators of hematopoietic stem cells and discusses their potential roles in the development and regeneration of tissues. The discussion focuses on the repair of neural tissues while parallels are made with bone marrow hematopoietic stem cells. Overall, the organization links the basic biology of SDF-1 alpha and CXCR4 to topics in medicine and show how any disease processes involving the SDF1 alpha-CXCR4 system could be central points in medicine. Discussions focused on potential therapies for SDF-1 and CXCR4 in clinical disorders. Breast and prostate cancers are selected as examples of solid tumors while leukemia is discussed as an example of hematological malignancies. Diffuse macular edema is discussed as potential therapy for a non-malignant disease.

引用

页码：319 / 329

页数：11

共 76 条

[1] Evidence that the number of hematopoietic stem cells per animal is conserved in mammals [J].