Recent advances in stealth coating of nanoparticle drug delivery systems

被引：390

作者：

Amoozgar, Zohreh ^{[1
]}

Yeo, Yoon ^{[1
,2
]}

机构：

[1] Purdue Univ, Dept Ind & Phys Pharm, Coll Pharm, W Lafayette, IN 47907 USA

[2] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA

来源：

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY | 2012年 / 4卷 / 02期

基金：

美国国家科学基金会;

关键词：

ACCELERATED BLOOD CLEARANCE; TARGETED TUMOR-CHEMOTHERAPY; PEGYLATED LIPOSOMES; POLYETHYLENE-GLYCOL; IN-VIVO; POLYMERIC MICELLES; CANCER-CHEMOTHERAPY; BLOCK-COPOLYMER; GENE DELIVERY; MACROMOLECULAR THERAPEUTICS;

D O I：

10.1002/wnan.1157

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Modifying surfaces of nanoparticles (NPs) with polyethylene glycol (PEG), the so-called PEGylation, is the most commonly used method for reducing premature clearance of NPs from the circulation. However, several reports point out that PEGylation may negatively influence the performance of NPs as a drug carrier. Alternative surface modification strategies, including substitute polymers, conditional removal of PEG, and biomimetic surface modification, may provide solutions for the limitations of PEG. WIREs Nanomed Nanobiotechnol 2012, 4:219233. doi: 10.1002/wnan.1157

引用

页码：219 / 233

页数：15

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