Interferon-inducible effector mechanisms in cell-autonomous immunity

被引：488

作者：

MacMicking, John D. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06510 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2012年 / 12卷 / 05期

基金：

美国国家卫生研究院;

关键词：

GUANYLATE-BINDING PROTEIN-1; STOMATITIS-VIRUS INFECTION; IRG RESISTANCE GTPASES; NITRIC-OXIDE SYNTHASE; TOXOPLASMA-GONDII; GAMMA-INTERFERON; HOST-RESISTANCE; MYCOBACTERIUM-TUBERCULOSIS; LISTERIA-MONOCYTOGENES; CHLAMYDIA-TRACHOMATIS;

D O I：

10.1038/nri3210

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Interferons (IFNs) induce the expression of hundreds of genes as part of an elaborate antimicrobial programme designed to combat infection in all nucleated cells-a process termed cell-autonomous immunity. As described in this Review, recent genomic and subgenomic analyses have begun to assign functional properties to novel IFN-inducible effector proteins that restrict bacteria, protozoa and viruses in different subcellular compartments and at different stages of the pathogen life cycle. Several newly described host defence factors also participate in canonical oxidative and autophagic pathways by spatially coordinating their activities to enhance microbial killing. Together, these IFN-induced effector networks help to confer vertebrate host resistance to a vast and complex microbial world.

引用

收藏

页码：367 / 382

页数：16

相关论文

共 165 条

[21]

The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway [J].

Cemma, Marija ;

Kim, Peter Kijun ;

Brumell, John Hunter .

AUTOPHAGY, 2011, 7 (03) :341-345

[22]

Chlamydia muridarum evades growth restriction by the IFN-γ-inducible host resistance factor Irgb10 [J].

Coers, Joern ;

Bernstein-Hanley, Isaac ;

Grotsky, David ;

Parvanova, Iana ;

Howard, Jonathan C. ;

Taylor, Gregory A. ;

Dietrich, William F. ;

Starnbach, Michael N. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (09) :6237-6245

[23]

Inactivation of LRG-47 and IRG-47 reveals a family of interferon γ-inducible genes with essential, pathogen-specific roles in resistance to infection [J].

Collazo, CM ;

Yap, GS ;

Sempowski, GD ;

Lusby, KC ;

Tessarollo, L ;

Woude, GFV ;

Sher, A ;

Taylor, GA .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (02) :181-187

[24]

Restriction of Toxoplasma gondii growth in human brain microvascular endothelial cells by activation of indoleamine 2,3-dioxygenase [J].

Däubener, W ;

Spors, B ;

Hucke, C ;

Adam, R ;

Stins, M ;

Kim, KS ;

Schroten, H .

INFECTION AND IMMUNITY, 2001, 69 (10) :6527-6531

[25]

Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense [J].

Degrandi, Daniel ;

Konermann, Carolin ;

Beuter-Gunia, Cornelia ;

Kresse, Alexandra ;

Wuerthner, Jan ;

Kurig, Stefanie ;

Beer, Sandra ;

Pfeffer, Klaus .

JOURNAL OF IMMUNOLOGY, 2007, 179 (11) :7729-7740

[26]

Type 1 interferon (IFNα/β) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite [J].

Diefenbach, A ;

Schindler, H ;

Donhauser, N ;

Lorenz, E ;

Laskay, T ;

MacMicking, J ;

Röllinghoff, M ;

Gresser, I ;

Bogdan, C .

IMMUNITY, 1998, 8 (01) :77-87

[27]

Opposing Biological Functions of Tryptophan Catabolizing Enzymes During Intracellular Infection [J].

Divanovic, Senad ;

Sawtell, Nancy M. ;

Trompette, Aurelien ;

Warning, Jamie I. ;

Dias, Alexandra ;

Cooper, Andrea M. ;

Yap, George S. ;

Arditi, Moshe ;

Shimada, Kenichi ;

DuHadaway, James B. ;

Prendergast, George C. ;

Basaraba, Randall J. ;

Mellor, Andrew L. ;

Munn, David H. ;

Aliberti, Julio ;

Karp, Christopher L. .

JOURNAL OF INFECTIOUS DISEASES, 2012, 205 (01) :152-161

[28]

The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15 [J].

Durfee, Larissa A. ;

Lyon, Nancy ;

Seo, Kyungwoon ;

Huibregtse, Jon M. .

MOLECULAR CELL, 2010, 38 (05) :722-732

[29]

Protein kinase R reveals an evolutionary model for defeating viral mimicry [J].

Elde, Nels C. ;

Child, Stephanie J. ;

Geballe, Adam P. ;

Malik, Harmit S. .

NATURE, 2009, 457 (7228) :485-U8

[30]

TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus [J].

Eldin, Patrick ;

Papon, Laura ;

Oteiza, Alexandra ;

Brocchi, Emiliana ;

Lawson, T. Glen ;

Mechti, Nadir .

JOURNAL OF GENERAL VIROLOGY, 2009, 90 :536-545

← 1 2 3 4 5 6 7 8 9 10 →