A Small Molecule Modulates Circadian Rhythms through Phosphorylation of the Period Protein

被引：48

作者：

Lee, Jae Wook ^{[1
,2
]}

Hirota, Tsuyoshi ^{[3
]}

Peters, Eric C. ^{[4
]}

Garcia, Michael ^{[4
]}

Gonzalez, Rodolfo ^{[1
,2
]}

Cho, Charles Y. ^{[4
]}

Wu, Xu ^{[4
]}

Schultz, Peter G. ^{[1
,2
]}

Kay, Steve A. ^{[3
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA

[4] Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 45期

关键词：

casein kinase; chemical biology; circadian rhythm; high-throughput screening; period proteins; SLEEP PHASE SYNDROME; REV-ERB-ALPHA; GENE-EXPRESSION; CLOCK PROTEIN; MUTATION; METABOLISM; INHIBITION; TAU; IDENTIFICATION; COMPONENTS;

D O I：

10.1002/anie.201103915

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Time shift: A high-throughput cell-based screen identified a benzothiazole analogue, LH846, which induces period lengthening of the circadian rhythm. Affinity chromatography coupled with mass spectrometry and genomic analysis identified protein kinase CKIδ as the biological target of LH846 (see picture). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：10608 / 10611

页数：4

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