Efficient enantioselective synthesis of 2-substituted thiomorpholin-3-ones

被引：9

作者：

Franceschini, N ^{[1
]}

Da Nascimento, S ^{[1
]}

Sonnet, P ^{[1
]}

Guillaume, D ^{[1
]}

机构：

[1] EA 2629, Lab Chim Therapeut, F-8000 Amiens, France

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 21期

关键词：

D O I：

10.1016/j.tetasy.2003.09.010

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of enantiomerically pure 4-(2-hydroxy-(1R)-phenylethyl)-thiomorpholin-3-one 2 from (R)-phenylglycine methyl ester, S-benzylthioglycolic acid and bromoacetic acid is reported. Stereoselective C-2 alkylation of 2, performed using various electrophiles, leads to enantiomerically pure 2-substituted thiomorpholin-3-ones after N-deprotection. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：3401 / 3405

页数：5

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